ศาสตราจารย์ ดร.บัณฑิต เจตน์สว่าง

The main area of my research interests is focusing on neurodegeneration, neuroprotection and neurorestorative especially the death and survival signaling cascades in neuronal cells and the protective roles of melatonin on neurodegeneration. My current research project is studying the role of methamphetamine-induced neurological and neuropsychological deficits related to cognitive impairment in cellular mechanisms, animal models and humans. I also study the regulation of tryptophan metabolism as a potential target to prevent neurodegeneration and cognitive impairments in the methamphetamine toxicity-induced neuroinflammation model.

Selected Publications

1. Kraiwattanapirom N, Siripornpanich V, Suwannapu W, Unaharassamee W, Chawang O, Lomwong N, Vittayatavornwong L, Chetsawang B. The quantitative analysis of EEG during resting and cognitive states related to neurological dysfunctions and cognitive impairments in methamphetamine abusers. Neurosci Lett. 2022 Sep 10;789:136870. doi: 10.1016/j.neulet.2022.136870.
2. Wiesmann D, Panmanee J, Mukda S, Chetsawang B. An in-silico study of structure-based virtual screening of IDO1 inhibitors as candidate compounds for drug development of IDO1-related diseases. J Basic App Pharmacol. Vol. 2 No.2 July- December 2022: O52-61.
3. Kraiwattanapirom N, Komlao P, Harnpramukkul A, Promyo K, Ngampramuan S, Chetsawang B. The neuroprotective role of melatonin against methamphetamine toxicity-induced neurotransmission dysregulation and cognitive deficits in rats. Food Chem Toxicol. 2021 Nov;157:112610. doi: 10.1016/j.fct.2021.112610.
4. Metasuk A, Kitiyanant N, Chetsawang B. An expression system of channelrhodopsin-2 driven by a minimal Arc/Arg3.1 promoter and Tet system was developed in human neuroblastoma cells. Plasmid. 2021 Aug 17;117:102597. doi: 10.1016/j.plasmid.2021.102597.
5. Promyo K, Iqbal F, Chaidee N, Chetsawang B. Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin. Food Chem Toxicol. 2020 Oct 29:111829. doi: 10.1016/j.fct.2020.111829.
6. Hein ZM, Kraiwattanapirom N, Mukda S, Chetsawang B. The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin. J Neuroimmunol 2020; Jul 15;344:577232. doi: 10.1016/j.jneuroim.2020.577232. Epub 2020 Apr 4.
7. Metasuk A, Kitiyanant N, Chetsawang B. Expression of nano-ferritin in neuronal cells encompassed by minimal Arc promoter system. Biochem Biophys Res Commun. 2020; 526(3), pp. 574-579
8. Premratanachai A, Suwanjang W, Govitrapong P, Chetsawang J, Chetsawang B. Melatonin prevents calcineurin-activated the nuclear translocation of nuclear factor of activated T-cells in human neuroblastoma SH-SY5Y cells undergoing hydrogen peroxide-induced cell death. J Chem Neuroanat. 2020 Jul;106:101793. doi: 10.1016/j.jchemneu.2020.101793. Epub 2020 Apr 26.
9. Thanontip K, Chetsawang B, Chumchua V. Novel protein-protein interaction network of antipsychotic drugs and cognitive function (Conference Paper). BMEiCON 2019 – 12th Biomedical Engineering International Conference November 2019, Article number 8990302.
10. Chetsawang J, Nudmamud-Thanoi S, Kraiwattanapirom N, Siripornpanich V, Unharasamee W, Chetsawang B. The effect of methamphetamine-induced neurodegeneration and psychiatric disorders on cognitive impairment in methamphetamine abusers in Thailand. J Pub Health Dev. 2019;17(1):15-29.
11. Phonchai R, Phermthai T, Kitiyanant N, Suwanjang W, Kotchabhakdi N, Chetsawang B. Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells. Neurochem Int. 2019 Mar;124:82-93.
12. Chetsawang J, Nudmamud-Thanoi S, Phonchai R, Abubakar Z, Govitrapong P, Chetsawang B. Methamphetamine toxicity-induced calcineurin activation, nuclear translocation of nuclear factor of activated T-cells and elevation of cyclooxygenase 2 levels are averted by calpastatin overexpression in neuroblastoma SH-SY5Y cells. Neurotoxicology. 2018 Jul;67:287-295.
13. Chatchaisak D, Connor M, Srikiatkhachorn A, Chetsawang B. The potentiating effect of calcitonin gene-related peptide on transient receptor potential vanilloid-1 activity and the electrophysiological responses of rat trigeminal neurons to nociceptive stimuli. J Physiol Sci. 2018; 68(3):261-268.
14. Parameyong A, Govitrapong P, Chetsawang B. Melatonin attenuates the mitochondrial translocation of mitochondrial fission proteins and Bax, cytosolic calcium overload and cell death in methamphetamine-induced toxicity in neuroblastoma SH-SY5Y cells. Mitochondrion. 2015; 24:1-8.
15. Chetsawang B, Putthaprasart C, Phansuwan-Pujito P, Govitrapong P. Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells: involvement of nuclear factor kappa B, Bax and Bcl-2. J. Pineal Res. 2006; 41:116-123.

Full Publications

1. Kraiwattanapirom N, Siripornpanich V, Suwannapu W, Unaharassamee W, Chawang O, Lomwong N, Vittayatavornwong L, Chetsawang B. The quantitative analysis of EEG during resting and cognitive states related to neurological dysfunctions and cognitive impairments in methamphetamine abusers. Neurosci Lett. 2022 Sep 10;789:136870. doi: 10.1016/j.neulet.2022.136870.
2. Wiesmann D, Panmanee J, Mukda S, Chetsawang B. An in-silico study of structure-based virtual screening of IDO1 inhibitors as candidate compounds for drug development of IDO1-related diseases. J Basic App Pharmacol. Vol. 2 No.2 July- December 2022: O52-61.
3. Kraiwattanapirom N, Komlao P, Harnpramukkul A, Promyo K, Ngampramuan S, Chetsawang B. The neuroprotective role of melatonin against methamphetamine toxicity-induced neurotransmission dysregulation and cognitive deficits in rats. Food Chem Toxicol. 2021 Nov;157:112610. doi: 10.1016/j.fct.2021.112610.
4. Metasuk A, Kitiyanant N, Chetsawang B. An expression system of channelrhodopsin-2 driven by a minimal Arc/Arg3.1 promoter and Tet system was developed in human neuroblastoma cells. Plasmid. 2021 Aug 17;117:102597. doi: 10.1016/j.plasmid.2021.102597.
5. Suwanjang W, Ruankham W, Chetsawang B, Mukda S, Ngampramuan S, Srisung S, Prachayasittikul V, Prachayasittikul S. Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats. Neurochem Int. 2021 May 27;148:105083. doi: 10.1016/j.neuint.2021.105083.
6. Promyo K, Iqbal F, Chaidee N, Chetsawang B. Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin. Food Chem Toxicol. 2020 Oct 29:111829. doi: 10.1016/j.fct.2020.111829.
7. Hein ZM, Kraiwattanapirom N, Mukda S, Chetsawang B. The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin. J Neuroimmunol 2020; Jul 15;344:577232. doi: 10.1016/j.jneuroim.2020.577232. Epub 2020 Apr 4.
8. Metasuk A, Kitiyanant N, Chetsawang B. Expression of nano-ferritin in neuronal cells encompassed by minimal Arc promoter system. Biochem Biophys Res Commun. 2020; 526(3), pp. 574-579
9. Premratanachai A, Suwanjang W, Govitrapong P, Chetsawang J, Chetsawang B. Melatonin prevents calcineurin-activated the nuclear translocation of nuclear factor of activated T-cells in human neuroblastoma SH-SY5Y cells undergoing hydrogen peroxide-induced cell death. J Chem Neuroanat. 2020 Jul;106:101793. doi: 10.1016/j.jchemneu.2020.101793. Epub 2020 Apr 26.
10. Thanontip K, Chetsawang B, Chumchua V. Novel protein-protein interaction network of antipsychotic drugs and cognitive function (Conference Paper). BMEiCON 2019 – 12th Biomedical Engineering International Conference November 2019, Article number 8990302.
11. Muangsab J, Prommeenate P, Chetsawang B, Chonpathompikunlert P, Sukketsiri W, Hutamekalin P. Protective effect of valproic acid on MPP+-induced neurotoxicity in dopaminergic SH-SY5Y cells through Cdk5/p35/Erk signaling cascade. Trop J Pharm Res 2019; 18 (11): 2255-2261.
12. Suwanjang W, Wu KLH, Prachayasittikul S, Chetsawang B, Charngkaew K. Mitochondrial Dynamics Impairment in Dexamethasone-Treated Neuronal Cells. Neurochem Res. 2019 Jul;44(7):1567-1581.
13. Chetsawang J, Nudmamud-Thanoi S, Kraiwattanapirom N, Siripornpanich V, Unharasamee W, Chetsawang B. The effect of methamphetamine-induced neurodegeneration and psychiatric disorders on cognitive impairment in methamphetamine abusers in Thailand. J Pub Health Dev. 2019;17(1):15-29.
14. Chatchaisak D, Chetsawang B, Chetsawang J. Effects of melatonin on dexamethasone-induced inflammation in trigeminal ganglion of mice. Siriraj Med J. 2019;71:(Suppl 1): S175-S179.
15. Abubakar Z, Chetsawang J, Chetsawang B. Roles of calpastatin overexpression on methamphetamine toxicity-induced mitochondrial dysfunction and cell degeneration in human neuroblastoma SH-SY5Y cells. Siriraj Med J. 2019;71: (Suppl 1): S180-S186.
16. Phonchai R, Phermthai T, Kitiyanant N, Suwanjang W, Kotchabhakdi N, Chetsawang B. Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells. Neurochem Int. 2019 Mar;124:82-93.
17. Wisessmith W, Shimizu T, Li J, Abe M, Sakimura K, Chetsawang B, Tanaka KF, Suzumura A, Tohyama K, Ikenaka K. Cathepsin C Modulates Myelin Oligodendrocyte Glycoprotein-induced Experimental Autoimmune Encephalomyelitis. J Neurochem. 2019 Feb;148(3):413-425.
18. Chetsawang J, Nudmamud-Thanoi S, Phonchai R, Abubakar Z, Govitrapong P, Chetsawang B. Methamphetamine toxicity-induced calcineurin activation, nuclear translocation of nuclear factor of activated T-cells and elevation of cyclooxygenase 2 levels are averted by calpastatin overexpression in neuroblastoma SH-SY5Y cells. Neurotoxicology. 2018 Jul;67:287-295.
19. Chatchaisak D, Connor M, Srikiatkhachorn A, Chetsawang B. The potentiating effect of calcitonin gene-related peptide on transient receptor potential vanilloid-1 activity and the electrophysiological responses of rat trigeminal neurons to nociceptive stimuli. J Physiol Sci. 2018; 68(3):261-268.
20. Chetsawang J, Mukda S, Srimokra R, Govitrapong P, Chetsawang B. Role of melatonin in reducing amphetamine-induced degeneration in substantia nigra of rats via calpain and calpastatin interaction. J Exp Neurosci 2017; 11:1–6.
21. Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K. The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model. Glia. 2017 Jun;65(6):917-930.
22. Tangmansakulchai K, Abubakar Z, Kitiyanant N, Suwanjang W, Leepiyasakulchai C, Govitrapong P, Chetsawang B. Calpastatin overexpression reduces oxidative stress-induced mitochondrial impairment and cell death in human neuroblastoma SH-SY5Y cells by decreasing calpain and calcineurin activation, induction of mitochondrial fission and destruction of mitochondrial fusion. Mitochondrion. 2016; 30:151-161.
23. Suwanjang W, Abramov AY, Charngkaew K, Govitrapong P, Chetsawang B. Melatonin prevents cytosolic calcium overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells. Neurochem Int. 2016; 97:34-41.
24. Singhakumar R, Boontem P, Ekthuwapranee K, Sotthibundhu A, Mukda S, Chetsawang B, Govitrapong P. Melatonin attenuates methamphetamine-induced inhibition of neurogenesis in the adult mouse hippocampus: An in vivo study Neurosci Lett. 2015; 606:209–214.
25. Parameyong A, Govitrapong P, Chetsawang B. Melatonin attenuates the mitochondrial translocation of mitochondrial fission proteins and Bax, cytosolic calcium overload and cell death in methamphetamine-induced toxicity in neuroblastoma SH-SY5Y cells. Mitochondrion. 2015; 24:1-8.
26. Sarlak G, Jenwitheesuk A, Chetsawang B, Govitrapong P. Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration. J Pharmacol Sci. 2013 Sep 20;123(1):9-24.
27. Parameyong A, Charngkaew K, Govitrapong P, Chetsawang B. Melatonin attenuates methamphetamine-induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH-SY5Y cells. J Pineal Res. 2013 Oct;55(3):313-323.
28. Suwanjang W, Abramov AY, Govitrapong P, Chetsawang B. Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells. J Steroid Biochem Mol Biol. 2013; 138C:116-122.
29. Pirompul N, Govitrapong P, Chetsawang B. Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells. Neurosci Lett. 2013; 545:138-143.
30. Suwanjang W, Holmström KM, Chetsawang B, Abramov AY. Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity. Cell Calcium 2013; 53:256-263.
31. Chatchaisak D, Srikiatkhachorn A, Maneesri le-Grand S, Govitrapong P, Chetsawang B. The role of calcitonin gene-related peptide on the increase in transient receptor potential vanilloid-1 levels in trigeminal ganglion and trigeminal nucleus caudalis activation of rat. J Chem Neuroanat 2013; 47:50-56.
32. Suwanjang W, Phansuwan-Pujito P, Govitrapong P, Chetsawang B. Calpastatin reduces calpain and caspase activation in methamphetamine-induced toxicity in human neuroblastoma SH-SY5Y cultured cells. Neurosci Lett 2012; 526:49-53.
33. Chetsawang J, Suwanjang W, Pirompul N, Govitrapong P, Chetsawang B. Calpastatin reduces methamphetamine-induced induction in c-Jun phosphorylation, Bax and cell death in neuroblastoma SH-SY5Y cells. Neurosci Lett 2012; 506:7-11.
34. Chetsawang J, Govitrapong P, Chetsawang B. Hydrogen peroxide toxicity induces Ras signaling in human neuroblastoma SH-SY5Y cultured cells. J Biomed Biotechnol 2010; 2010.pii:803815.
35. Suwanjang W, Phansuwan-Pujito P, Govitrapong P, Chetsawang B. The protective effect of melatonin on methamphetamine-induced calpain-dependent death pathway in human neuroblastoma SH-SY5Y cultured cells. J Pineal Res 2010; 48:94-101.
36. Wisessmith W, Phansuwan-Pujito P, Govitrapong P, Chetsawang B. Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cells. J Pineal Res 2009; 46:433-440.
37. Chetsawang B, Chetsawang J, Govitrapong P. Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP+-treated human neuroblastoma cells with melatonin. J. Pineal Res. 2009; 46: 36-42.
38. Chetsawang B, Kooncumchoo P, Govitrapong P, Ebadi M. 1-methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline. Neurochem Int. 2008; 53: 283-288.
39. Chetsawang J, Govitrapong P, Chetsawang B. Melatonin inhibits MPP+-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells. J. Pineal Res. 2007; 43: 115-120.
40. Chucharoen P, Chetsawang B, Putthaprasart C, Srikiatkhachorn A, Govitrapong P. The presence of melatonin receptors and inhibitory effect of melatonin on hydrogen peroxide-induced endothelial nitric oxide synthase expression in bovine cerebral blood vessels. J. Pineal Res. 2007; 43: 35-41.
41. Chetsawang B, Putthaprasart C, Phansuwan-Pujito P, Govitrapong P. Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells: involvement of nuclear factor kappa B, Bax and Bcl-2. J. Pineal Res. 2006; 41:116-123.
42. Phansuwan-Pujito P, Boontem P, Chetsawng B, Ebadi M. Govitrapong P. Dopamine transporter immunoreactive terminals in the bovine pineal gland. Neurosci. Lett. 2006; 403:78-83.
43. Chetsawang B, Govitrapong P. Stimulatory effect of morphine on rat pineal melatonin synthesis via a cyclic AMP-dependent transcription pathway. Neurosci. Lett. 2005; 389: 57-60.
44. Mukda S, Chetsawang B, Govitrapong P, Schmidt PT, Hay-Schmidt A, Moller M. Tachykinin and tachykinin-receptors in the rat pineal gland. Eur. J. Neurosci. 2005; 21: 2743-2751.
45. Chesawang B, Govitrapong P, Ebadi M. The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells. Neurosci. Lett. 2004; 371: 205-208.
46. Santanavanich C, Chetsawang B, Ebadi M, Govitrapong P. Effects of D1- and D2-dopamine receptor activation on melatonin synthesis in bovine pinealocytes. J. Pineal Res. 2003; 35 (3):169-176.
47. Jongkamonwiwat N, Phansuwan-Pujito P, Sarapoke P, Chetsawang B, Casalotti SO, Forge A, Dodson H, Govitrapong P. The presence of opioid receptors in rat inner ear.Hear Res. 2003 Jul; 181(1-2):85-93.
48. Chucharoen P, Chetsawang B, Srikiatkhachorn A, Govitrapong P. Melatonin receptor expression in rat cerebral artery. Neurosci. Lett. 2003 May 8; 341(3):259-261.
49. Ebadi M, Sharma S, Muralikrishnan D, Shavali S, Eken J, Sangchot P, Chetsawang B, Brekke L. Metallothionein provides ubiquinone-mediated neuroprotection in Parkinson’s disease. Proc. West. Pharmacol. Soc. 2002; 45:36-38.
50. Govitrapong P, Sawlom S, Chetsawang B, Sangchot P, Ebadi M. The bovine pineal gland contains delta and mu but not kappa or ORL1 opioid receptor subtypes. Proc. West. Pharmacol. Soc. 2002; 45:32-35.
51. Sangchot P, Sharma S, Chetsawang B, Porter J, Govitrapong P, Ebadi M. Deferoxamine attenuates iron-induced oxidative stress and prevents mitochondrial aggregation and alpha-synuclein translocation in SK-N-SH cells in culture. Dev. Neurosci. 2002; 24(2-3):143-153.
52. Chetsawang B, Govitrapong P, Møller M. The effects of adrenergic agonists on c-fos, jun-B and nitric oxide synthase-like immunoreactivities in cultured rat pinealocytes. J. Pineal Res. 2001; 31: 186-192.
53. Chetsawang B, Casalotti SO, Phansuwan-Pujito P, Kotchabhakdi N, Govitrapong P. Gene expressions of opioid receptors and G-proteins in pineal glands. Biochem. Biophys. Res. Commun. 1999; 262(3): 775-780.
54. Govitrapong P, Jitjaijamjang W, Chetsawang B, Phansuwan-Pujito P, Ebadi, M. Existence and function of opioid receptors on mammalian pinealocytes. J. Pineal Res. 1998; 24: 201-208.
55. Chetsawang B, Riol H, Levesque G, Murthy, MRV. Transcription of “slow virus” dementia prion protein gene in lymphocytes of human blood. J. Sci. Soc. Thailand 1993; 19: 97-102.
56. Chetsawang B, Kotchabhakdi N, Cherdchu C, Govitrapong P. Collagenase diminished muscarinic receptor binding in partially purified bovine adrenal chromaffin cells. J. Sci. Soc. Thailand 1990; 16(3/4): 177-185.