อ.ดร.ชุติมา เทพฤทธิ์

Chutima Thepparit, Ph.D.

Ph.D. (Molecular Genetics and Genetic Engineering), Mahidol University, 2005
Ext. 1420
Email:  chutima.thp@mahidol.ac.th
Field of Research: Virus-host cells interaction, Vaccine development

With Mahidol Vaccine Development Consortium, our current research focuses on development of hand foot and mouth disease vaccine. We have screened for the causative strains of hand foot and mouth disease including Enterovirus 71 and Coxackievirus which provides broad cross protection against variant strains to be developed as the inactivated vaccine against hand foot and mouth disease. In parallel, as part of the Molecular Pathology Laboratory, I have been investigating the dengue virus and host cell interactions including the step of viral entry and host cell response to viral infection to understand dengue viral pathogenesis .

Selected Publications

1. Fongsaran C., Jirakanwisal K., Kuadkitkan A., Wikan N., Wintachai P., Thepparit C., Ubol S., Phaonakrop N., Roytrakul S., and Smith D. R.* Involvement of ATP synthase beta subunit in chikungunya virus entry to insect cells. Arch Virol. 2014. In Press.

2. Fongsaran C., Phaonakrop N., Roytrakul S., Thepparit C., Kuadkitkan A., and Smith D. R.* Voltage Dependent Anion Channel Is Redistributed during Japanese Encephalitis Virus Infection of Insect Cells. ScientificWorldJournal. 2014. In Press.

3. Petchampai, N., Sunyakumthorn, P., Guillotte, M. L., Thepparit, C., Kearney, M. T., Mulenga, A., Azad, A. F., and Macaluso, K. R.* Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis. Insect Mol Biol. 2014. 23(1):42-51.

4. Thepparit, C., Khakpoor, A., Khongwichit, S., Wikan, N., Fongsaran, C., Chingsuwanrote, P., Panraksa, P., and Smith, D. R.* Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death. BMC Res Notes. 2013. 6:372.

5. Thepparit, C.*, Hirunkanokpun, S., Popov, V. L., Foil, L. D., and Macaluso, K. R. Dissemination of bloodmeal acquired Rickettsia felis in cat fleas, Ctenocephalides felis. Parasit.Vectors. 6(1), 149. 5-24-2013.

Full Publications

1. Fongsaran C., Jirakanwisal K., Kuadkitkan A., Wikan N., Wintachai P., Thepparit C., Ubol S., Phaonakrop N., Roytrakul S., and Smith D. R.* Involvement of ATP synthase beta subunit in chikungunya virus entry to insect cells. Arch Virol. 2014. In Press.

2. Fongsaran C., Phaonakrop N., Roytrakul S., Thepparit C., Kuadkitkan A., and Smith D. R.* Voltage Dependent Anion Channel Is Redistributed during Japanese Encephalitis Virus Infection of Insect Cells. ScientificWorldJournal. 2014. In Press.

3. Petchampai, N., Sunyakumthorn, P., Guillotte, M. L., Thepparit, C., Kearney, M. T., Mulenga, A., Azad, A. F., and Macaluso, K. R.* Molecular and functional characterization of vacuolar-ATPase from the American dog tick Dermacentor variabilis. Insect Mol Biol. 2014. 23(1):42-51.

4. Thepparit, C., Khakpoor, A., Khongwichit, S., Wikan, N., Fongsaran, C., Chingsuwanrote, P., Panraksa, P., and Smith, D. R.* Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death. BMC Res Notes. 2013. 6:372.

5. Thepparit, C.*, Hirunkanokpun, S., Popov, V. L., Foil, L. D., and Macaluso, K. R. Dissemination of bloodmeal acquired Rickettsia felis in cat fleas, Ctenocephalides felis. Parasit.Vectors. 6(1), 149. 5-24-2013.

6. Thongtan, T., Thepparit, C., and Smith, D. R.* The involvement of microglial cells in Japanese encephalitis infections. Clin.Dev Immunol. 2012. 890586.

7. Hirunkanokpun, S., Thepparit, C., Foil, L. D., and Macaluso, K. R.* Horizontal transmission of Rickettsia felis between cat fleas, Ctenocephalides felis. Mol Ecol. 2011. 20(21):4577-4586.

8. Thepparit, C., Sunyakumthorn, P., Guillotte, M. L., Popov, V. L., Foil, L. D., and Macaluso, K. R.* Isolation of a rickettsial pathogen from a non-hematophagous arthropod. PLoS One. 2011. 6(1):e16396.

9. Thepparit, C., Bourchookarn, A., Petchampai, N., Barker, S. A., and Macaluso, K. R.* Interaction of Rickettsia felis with histone H2B facilitates the infection of a tick cell line. Microbiology 2010. 156(Pt 9):2855-2863.

10. Castino, R., Thepparit, C., Bellio, N., Murphy, D., and Isidoro, C.* Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression. J Neuroendocrinol. 2008. 20(10):1165-1175.

11. Cabrera-Hernandez, A., Thepparit, C., Suksanpaisan, L., and Smith, D. R.* Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70. J Med.Virol. 2007. 79(4):386-392.

12. Thepparit, C. and Smith, D. R.* Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor. J Virol. 2004. 78(22):12647-12656.

13. Thepparit, C., Phoolcharoen, W., Suksanpaisan, L., and Smith, D. R.* Internalization and propagation of the dengue virus in human hepatoma (HepG2) cells. Intervirology 2004. 47(2):78-86.

14. Jindadamrongwech, S., Thepparit, C., and Smith, D. R.* Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2. Arch Virol. 2004. 149(5):915-927.

15. Sithisarn, P., Suksanpaisan, L., Thepparit, C., and Smith, D. R.* Behavior of the dengue virus in solution. J Med.Virol. 2003. 71(4):532-539.

16. Thepparit, C., Sonthayanon, B., Udomkit, A., Panyim, S., and Smith, D. R.* Molecular characterization of cDNA’s obtained from black tiger shrimp (Penaeus monodon) haemocytes through the use of degenerate primers. Asia-Pacific Journal of Molecular Biology and Biotechnology. 2002. 10(1):31-39.