Surapon Piboonpocanun

Our current research aims:
1) To elucidate mechanism of house dust mite major allergen and its lipid ligands triggering inflammation responses from innate and adaptive immune cells and from lung epithelial cells.
2) To identify and characterize novel food allergens in wheat flour causing wheat-dependent, exercise induced anaphylaxis (WDEIA) in Thai children.
3) To determine roles of miRNA in regulating expression of Th2 type cytokines in innate immune cells and from lung epithelial cells.

 Selected Publications

1. Tanyaratsrisakul S, Jirapongsananuruk O, Kulwanich B, Hales BJ, Thomas WR, *Piboonpocanun S. Effect of Amino Acid Polymorphisms of House Dust Mite Der p 2 Variants on Allergic Sensitization. Allergy Asthma Immunol Res. 2016; 8:55-62.

2.*Piboonpocanun S, Jirapongsananuruk O, Tipayanon T, Boonchoo S, Goodman RE. Identification of hemocyanin as a novel non-cross-reactive allergen from thegiant freshwater shrimp Macrobrachiumrosenbergii. MolNutr Food Res. 2011; 55:1492-8.

3. Tanyaratsrisakul S, Malainual N, Jirapongsananuruk O, Smith WA, Thomas WR, *Piboonpocanun S. Structural and IgE binding analyses of recombinant Der p 2 expressed from the hosts Escherichia coli and Pichiapastoris. Int Arch Allergy Immunol 2010; 151:190–198.

4.*Piboonpocanun S, Malainual N, Jirapongsananurk O, Vichyanond P, Thomas W.R. Genetic polymorhisms of major house dust mite allergens. ClinExp Allergy. 2006;36,510-516.

5. Piboonpocanun S, Chiba H, Mitsuzawa H, Martin W, Murphy RC, Harbeck RJ, Voelker DR. Surfactant protein A binds Mycoplasma pneumoniae with high affinity and  attenuates its growth by recognition of Disaturated-Phosphatidylglycerols. J Biol Chem. 2005; 280: 9-17.

Full Publications

1. Soh WT, Le Mignon M, Suratannon N, Satitsuksanoa P, Chatchatee P, Wongpiyaboron J, Vangveravong M, Rerkpattanapipat T, Sangasapaviliya A, Nony E, Piboonpocanun S, Ruxrungtham K, Jacquet A; Mite Allergy Research Cohort (MARC) Study Team. The House Dust Mite Major Allergen Der p 23 Displays O-Glycan-Independent IgE Reactivities but No Chitin-Binding Activity. Int Arch Allergy Immunol. 2015; 168: 150-60.

2. Tanyaratsrisakul S, Jirapongsananuruk O, Kulwanich B, Hales BJ, Thomas WR, *Piboonpocanun S. Effect of Amino Acid Polymorphisms of House Dust Mite Der p 2 Variants on Allergic Sensitization. Allergy Asthma Immunol Res. 2016; 8: 55-62.

3. Siriwattanakul U, Piboonpocanun S, Traiperm P, Pichakam A, Songnuan W. Amaranthus species around Bangkok, Thailand and the release of allergenic proteins from their pollens. Asian Pac J Allergy Immunol. 2015; 33: 203-10.

4. Pariyaprasert W, Piboonpocanun S, Jirapongsananuruk O, Visitsunthorn N. Stability and potency of raw and boiled shrimp extracts for skin prick test. Asian Pac J Allergy Immunol. 2015; 33: 136-42.

5. Wongkaewpothong P, Pacharn P, Sripramong C, Boonchoo S, Piboonpocanun S, Visitsunthorn N, Vichyanond P, Jirapongsananuruk O. The utility of serum tryptase in the diagnosis of food-induced anaphylaxis. Allergy Asthma Immunol Res. 2014; 6: 304-9.

6. Hales BJ, Elliot CE, Chai LY, Pearce LJ, Tipayanon T, Hazell L, Stone S, Piboonpocanun S, Thomas WR, Smith WA. Quantitation of IgE binding to the chitinase and chitinase-like house dust mite allergens Der p 15 and Der p 18 compared to the major and mid-range allergens. Int Arch Allergy Immunol. 2013;160(3):233-40.

7. Jirapongsananuruk O, Luangwedchakarn V, Niemela JE, Pacharn P, Visitsunthorn N, Thepthai C, Vichyanond P, Piboonpocanun S, Fleisher TA. Cryptococcal osteomyelitis in a child with a novel compound mutation of the IL12RB1 gene. Asian Pac J Allergy Immunol. 2012;30:79-82.

8. Smith W, O’Neil SE, Hales BJ, Chai TL, Hazell LA, Tanyaratsrisakul S, Piboonpocanun S, Thomas WR. Two newly identified cat allergens: the von Ebner gland protein Fel d 7 and the latherin-like protein Fel d 8. Int Arch Allergy Immunol. 2011;156:159-70.

9. *Piboonpocanun S, Jirapongsananuruk O, Tipayanon T, Boonchoo S, Goodman RE. Identification of hemocyanin as a novel non-cross-reactive allergen from the giant freshwater shrimp Macrobrachium rosenbergii. Mol Nutr Food Res. 2011;55:1492-8.

10. Jirapongsananuruk O, Jirarattanasopa N, Pongpruksa S, Vichyanond P, Piboonpocanun S. Glyceraldehyde-3-phosphate dehydrogenase as a major allergen in rambutan-induced anaphylaxis. Ann Allergy Asthma Immunol. 2011;106:545-7.

11. Pulsawat P, Piboonpocanun S, Sirivichayakul S, Buranapraditkun S, Jacquet A, Shimada M, Okuda K, Ruxrungtham K. Production and immunogenicity of hypoallergenic codon-optimized DNA vaccine encoding mature Der p 1 allergen. J Investig Allergol Clin Immunol. 2010;20:582-90.

12. Piboonpocanun S, Boonchoo S, Pariyaprasert W, Visitsunthorn N, Jirapongsananuruk O. Determination of storage conditions for shrimp extracts: analysis of specific IgE-allergen profiles. Asian Pac J Allergy Immunol. 2010;28:47-52.

13. Tanyaratsrisakul S, Malainual N, Jirapongsananuruk O, Smith WA, Thomas WR, *Piboonpocanun S. Structural and IgE binding analyses of recombinant Der p 2 expressed from the hosts Escherichia coli and Pichia pastoris. Int Arch Allergy Immunol. 2010;151:190-8.

14. Luangwedchakarn V, Jirapongsaranuruk O, NiemeLa JE, Thepthai C, Chokephaibulkit K, Sukpanichnant S, Pacharn P, Visitsunthorn N, Vichyanond P, Piboonpocanun S, Fleisher TA. A novel mutation of the IL12RB1 gene in a child with nocardiosis, recurrent salmonellosis and neurofibromatosis type I: first case report from Thailand. Asian Pac J Allergy Immunol. 2009;27:161-5.

15. Jirapongsananuruk O, Sripramong C, Pacharn P, Udompunturak S, Chinratanapisit S, Piboonpocanun S, Visitsunthorn N, Vichyanond P. Specific allergy to P. monodon (seawater shrimp) or M. rosenbergii (freshwater shrimp) in shrimp-allergic children. Clin Exp Allergy. 2008; 38: 1038-1047.

16. Jirapongsananuruk O, Noack D, Boonchoo S, Thepthai C, Chokephaibulkit K, Visitsunthorn N, Vichyanond P, Luangwedchakarn V, Likasitwattanakul S, *Piboonpocanun S. A novel mutation of the CYBB gene resulting in severe form of x-linked chronic granulomatous disease. Asian Pac J Allergy Immunol 2007; 25: 249-252.

17. *Piboonpocanun S, Malainual N, Jirapongsananuruk O, Vichyanond P, Thomas WR. Genetic polymorphisms of major house dust mite allergens. Clin Exp Allergy 2006; 36: 510-516.

18. Chiba H, Piboonpocanun S, Mitsuzawa H, Kuronuma K, Murphy RC, Voelker DR. Pulmonary surfactant proteins and lipids as modulators of inflammation and innate immunity. Respirology 2006; 11: S2-S6.

19. Piboonpocanun S, Chiba H, Mitsuzawa H, Martin W, Murphy RC, Harbeck RJ, Voelker DR. Surfactant protein A binds Mycoplasma pneumoniae with high affinity and attenuates its growth by recognition of Disaturated-Phosphatidylglycerols. J Biol Chem. 2005; 280: 9-17.

20. Chiba H, Pattanajitvilai S, Mitsuzawa H, Kuroki Y, Evans AJ, Voelker DR. Pulmonary surfactant proteins A and D recognize lipid ligands on Mycoplasma pneumoniae and markedly augment the innate immune response to the organism. Chest. 2003; 123: 426S.

21. Chiba H, Pattanajitvilai S, Evans AJ, Harbeck RJ, Voelker DR. Human Surfactant protein D (SP-D) binds Mycoplasma pneumoniae by high affinity interactions with lipids. J Biol Chem. 2002; 277: 20379-85.

22. Pattanajitvilai S, Kuroki Y, Tsunezawa W, McCormack FX, Voelker DR. Mutational analysis of arg197 of rat surfactant protein A. His197 creates specific lipid uptake defects. 1998 J Biol Chem. 273, 5702-5707.

23. McCormack FX, Pattanajitvilai S, Stewart J, Possmayer F, Inchly K, Voelker DR. The cys6 intramolecular disulfide bond and the collagen-like region of rat SP-A play critical roles in interactions with alveolar type II cells and surfactant lipids. 1997 J. Biol. Chem. 272, 27971-27979.

24. Schanbacher FL, Pattanajitvilai S, Neville MC. 1997 Posttranscriptional regulation of bovine and human lactoferrin: Species differences and Influence of mRNA regions. In: Lactoferrin: Interactions and Biological Functions, Humana Press Inc., Totowa, NJ.