Varaporn Akkarapatumwong, Ph.D., Assoc. Prof.
Conservation Genetics and Ecology
|Ph.D.(Science), University of Adelaide, Australia
Field of Research: Molecular Basis of Genetic Diseases
My laboratory is interested in investigation the molecular basis of human diseases such as distal renal tubular acidosis (dRTA) and renal stone formation in collaboration with Prof. Pa-thai Yenchitsomanus. Both dRTA and renal stone are diseases which commonly found in the northeastern population of Thailand. Several evidences suggested that genetic factors may play an important role in causing these diseases. Our research goal for dRTA is to investigate the molecular defects causing dRTA by several approaches including mutation analysis and functional analysis. Yeast two-hybrid screening was used to search for protein interacting with kAE1, an isoform of AE1 in kidney. Integrin-linked kinase (ILK) was obtained as one of the protein interacting with kAE1 and detail analysis of the interaction of ILK and kAE1 was performed in collaboration with Prof. Joe Casey. For the research work in renal stone formation, we are part of the ongoing project aimed to identify candidate genes for this disease. Association studies using single nucleotide polymorphisms (SNPs) was conducted to study the selected genes that may associated with renal stone formation.