(Mapping Analogous Nuclei Onto Residue And Affinity) for identifying protein-ligand fragment interaction, pathways and SNPs.
The acronym “Manoraa” is a Thai word used for calling a dancing lady in ancient Thai Musicals. The server Mapping Analogous Nuclei onto Residue And Affinity (MANORAA) provides 3D visualization of fragment–residue interaction between the chemicals and multiple protein binding partners in the Protein Data Bank. In addition to providing the interaction type and the amount of bonds that the fragment made which shows to affect binding affinity, it also shows linkage to Single Nucleotide Polymorphisms, biochemical pathways, protein and RNA baseline expression, and diseases. The server can open door for a more robust and insightful analysis for the study of species selectivity, off-target inhibition that causes drug side effect, and multi-target drug design.
Tanramluk D, Narupiyakul L, Akavipat R, Gong S, Charoensawan V. (2016) MANORAA (Mapping Analogous Nuclei Onto Residue And Affinity) for identifying protein-ligand fragment interaction, pathways and SNPs. Nucl. Acids Res. 44 (W1): W514-W521.