Molecular Medical Biosciences Cluster
New insights into specific disease processes are the basis of new applications in clinical care and treatment. We integrate the most recent knowledge and technology in cell and molecular biology with innovative ideas to study human diseases that represent the major public health concerns in Thailand .
Studies an interaction of mosquito larvicidal toxins and their receptors Aedes aegypti mosquito is an important vector of dengue fever causing global death. Cry4 and Cry11 toxins produced from the Bacillus thuringiensis bacteria are specifically toxic to mosquito larvae. I am interested in an action mechanism of Cry4Ba, toxin-receptor interaction with its applications through structure-function relationship, cytolytic pore-formation, cellular & molecular biology and immunological techniques.
Introduction: Less than 3% of the human genome encodesproteins, and more than half of the transcripts in human appear to be non-coding (nc) RNAs. This fact redefined the paradigm of genetic flow (The Central Dogma), and shed light on the hidden roles of ncRNAs in regulation of cellular processes. There are likely to be many more unknown ncRNAs that are fulfilling a wide range of unexpected functions in eukaryotic biology.
Our major goal is to promote the development of innovative discoveries and translational strategies related to stem cells. We are interested in understanding the mechanisms of blood and neural development, modeling blood and neural disorders, and direct converting of adult fibroblast into other specific lineage.