ผู้ช่วยศาสตราจารย์ ดร.อลิตา คงชนะกุล – สถาบันชีววิทยาศาสตร์โมเลกุล

ผู้ช่วยศาสตราจารย์ ดร.อลิตา คงชนะกุล

ผู้ช่วยผู้อำนวยการ ฝ่ายกิจการนักศึกษา และกิจกรรมพิเศษ

Ph.D. (Immunology), Faculty of Medicine Siriraj Hospital, Mahidol University, 2011
B.Biotech Hons. (Microbial Biotechnology), The University of Queensland, 2003
Ext. 1420
Email:alita.kon@mahidol.ac.th
Field of Research:Vaccine Research and Development

Research and development on live attenuated tetravalent dengue vaccine with safety and ability to provide long lasting protective immunity has been pursued since 1980. Vaccine production was achieved by serially passages of dengue viruses in the certified cells under GLP compliance and guidance by WHO Peer Review Committee. We aim at 1-2 doses vaccine which could be able to produce a life-long protective immunity. Beside dengue vaccine, development of JE live and inactivated vaccine are also in progress with satisfactory outcome.

Facilities for laboratory testing as well as experience personnel offer CVD to serve as a WHO Reference laboratory on serology and virology for dengue and JE viruses. Samples from various countries were sent through WHO/TDR network to CVD for laboratory testing or standardizing as well as for evaluating of the vaccine products or diagnostic test kits. Training for scientists from various countries, for example, the course under PDVI programme has been successfully accomplished by the team of scientists at CVD. More than 20 years experience on dengue diagnosis has been approved not only by WHO Peer Review Committee but also by the quality assurance teams from various private vaccine industries.

We also provide dengue and JE diagnostic on serology and virology as well as candidate vaccine evaluation for academic contribution such as; Plaque size morphology of DEN-4 parental and candidate vaccine strainsPlaque strains Preparation of certified cells for dengue vaccine Preparation vaccine.

At present, networks with Thai researchers and vaccine industries from several countries have been lunched for collaboration in dengue and JE vaccine research and development. Besides, both basic and applied research leading to the development of knowledge and technologies for dengue and JE diseases are in progress and also open for collaborations.

Selected Publications

1: Suptawiwat O, Jeamtua W, Boonarkart Ch, Kongchanagul A, Puthawathana P, Auewarakul P. Effects of the Q223R mutation in the hemagglutinin (HA) of egg-adapted pandemic 2009 (H1N1) influenza A virus on virus growth and binding of HA to human- and avian-type cell receptors. Acta Virol. 2013;57(3):333-8.

2: Noisumdaeng P, Pooruk P, Kongchanagul A, Assanasen S, Kitphati R, Auewarakul P, Puthavathana P. Biological properties of H5 hemagglutinin expressed by vaccinia virus vector and its immunological reactivity with human sera. Viral Immunol. 2013 Feb;26(1):49-59.

3: Kongchanagul A, Rodpothong P, Suriyapho P, Wiriyarat W, Chaichuen K, Suptawiwat O, Thitithanyanont A, Auewarakul P, Puthavathana P. Evolutionary changes in avian influenza H5N1 viruses in Thailand. Acta Virol. 2012;56(3):257-9.

4: Boonarkart CH, Suptawiwat O, Uiprasertkul M, Kongchanagul A, Rodpothong P, Bunthi CH, Champunot R, Auewarakul P. A reduced expression of surfactant protein D in the lungs of fatal influenza H1N1 cases in 2009. Acta Virol. 2012;56(3):253-5.

5: Tan GS, Krammer F, Eggink D, Kongchanagul A, Moran TM, Palese P. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J Virol. 2012 Jun;86(11):6179-88.

Full Publications

5: Tan GS, Krammer F, Eggink D, Kongchanagul A, Moran TM, Palese P. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J Virol. 2012 Jun;86(11):6179-88.

6: Kongchanagul A, Suptawiwat O, Boonarkart C, Kitphati R, Puthavathana P, Uiprasertkul M, Auewarakul P. Decreased expression of surfactant protein D mRNA in human lungs in fatal cases of H5N1 avian influenza. J Med Virol. 2011 Aug;83(8):1410-7.

7: Auewarakul P, Chatsurachai S, Kongchanagul A, Kanrai P, Upala S, Suriyaphol P, Puthavathana P. Codon volatility of hemagglutinin genes of H5N1 avian influenza viruses from different clades. Virus Genes. 2009 Jun;38(3):404-7.

8: Kongchanagul A, Suptawiwat O, Kanrai P, Uiprasertkul M, Puthavathana P, Auewarakul P. Positive selection at the receptor-binding site of haemagglutinin H5 in viral sequences derived from human tissues. J Gen Virol. 2008 Aug;89(Pt8):1805-10.

9: Suptawiwat O, Kongchanagul A, Chan-It W, Thitithanyanont A, Wiriyarat W, Chaichuen K, Songserm T, Suzuki Y, Puthavathana P, Auewarakul P. A simple screening assay for receptor switching of avian influenza viruses. J Clin Virol. 2008 Jun;42(2):186-9.

10: Auewarakul P, Suptawiwat O, Kongchanagul A, Sangma C, Suzuki Y, Ungchusak K, Louisirirotchanakul S, Lerdsamran H, Pooruk P, Thitithanyanont A, Pittayawonganon C, Guo CT, Hiramatsu H, Jampangern W, Chunsutthiwat S, Puthavathana P. An avian influenza H5N1 virus that binds to a human-type receptor. J Virol. 2007 Sep;81(18):9950-5.

11: Uiprasertkul M, Kitphati R, Puthavathana P, Kriwong R, Kongchanagul A, Ungchusak K, Angkasekwinai S, Chokephaibulkit K, Srisook K, Vanprapar N, Auewarakul P. Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans. Emerg Infect Dis. 2007 May;13(5):708-12.