ผู้ช่วยศาสตราจารย์ ดร.สุจิรา มุกดา – สถาบันชีววิทยาศาสตร์โมเลกุล

รองศาสตราจารย์ ดร.สุจิรา มุกดา

Ph.D.(Neuroscience), Mahidol University, Thailand
Ext:1206
Email: sujira.muk@mahidol.ac.th

Research interest:

Melatonin, Drug addiction, Cerebrovascular disease, Aging, Circadian rhythm and Clock genes

Our current research interests are primarily on the neurobiological consequences of drug abuse and addiction on the brain and behaviors. The purpose of our work aims to approach the vulnerabilities of addiction emphasizing on the neurotoxicity, neuronal cell degeneration, neuroinflammation, cognitive impairment, and neurodevelopmental deficits, as well as the accompanying changes in the brain areas involved in drug addiction and cognition.

In addition, our research interests are also focusing on how drugs of abuse impact the molecular and physiological circadian clocks, and vice versa, how disruption of the circadian rhythms plays a key part in regulating the brain’s reward-related pathways. The therapeutic approach that reset the circadian rhythm contributes to clock-drug interactions will also be studied.

Another research study in our lab is focusing on the neurobiological consequences of cerebrovascular disease (stroke), particularly after a transient ischemic stroke, which results in neuronal cell death and eventually leads to serious neurological consequences including cognitive impairments and dementia. Our research aims are focusing on the signaling molecules crucial for memory formation, and develop the therapeutic approaches to slow down the progression of memory and cognitive deficits after stroke.

Selected Publications

2.Hsu SY, Chen CH, Mukda S, Leu S. Neuronal Pnn Deficiency Increases Oxidative Stress and Exacerbates Cerebral Ischemia/Reperfusion Injury in Mice. Antioxidants (Basel). 2022;11(3).

3.Veschsanit N, Yang JL, Ngampramuan S, Viwatpinyo K, Pinyomahakul J, Lwin T, Chancharoen, P, Rungruang, S, Govitrapong, P, Mukda, S. Melatonin reverts methamphetamine-induced learning and memory impairments and hippocampal alterations in mice. Life Sci. 2021;265:118844.

4.Lwin T, Yang JL, Ngampramuan S, Viwatpinyo K, Chancharoen P, Veschsanit N, Pinyomahakul J, Govitrapong P, Mukda, S. Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFkappaB signaling pathway in the mouse hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110109.

5.Hsu SY, Mukda S, Leu S. Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation. Brain Sci. 2020;10(10):708.

6.Yang JL, Chen WY, Mukda S, Yang YR, Sun SF, Chen SD. Oxidative DNA damage is concurrently repaired by base excision repair (BER) and apyrimidinic endonuclease 1 (APE1)-initiated nonhomologous end joining (NHEJ) in cortical neurons. Neuropathol Appl Neurobiol. 2020;46(4):375-90.

7. Mukda S, Tsai CY, Leu S, Yang JL, Chan SHH. Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions. J Biomed Sci. 2019;26(1):43.

8.Yang JL, Mukda S, Chen SD. Diverse roles of mitochondria in ischemic stroke. Redox Biol. 2018;16:263-75.

9.Permpoonputtana K, Tangweerasing P, Mukda S, Boontem P, Nopparat C, Govitrapong P. Long-term administration of melatonin attenuates neuroinflammation in the aged mouse brain. EXCLI J. 2018;17:634-46.

10.Wongchitrat P, Lansubsakul N, Kamsrijai U, Sae-Ung K, Mukda S, Govitrapong P. Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis. Neurochem Int. 2016;100:97-109.

11.Mukda S, Panmanee J, Boontem P, Govitrapong P. Melatonin administration reverses the alteration of amyloid precursor protein-cleaving secretases expression in aged mouse hippocampus. Neurosci Lett. 2016;621:39-46.

Full Publications

1.Promthep K, Nopparat C, Mukda S, Pannengpetch S, Wisomka P, Chantadul V, et al. Proteomic profiling reveals neuronal ion channel dysregulation and cellular responses to DNA damage-induced cell cycle arrest and senescence in human neuroblastoma SH-SY5Y cells exposed to cypermethrin. Neurotoxicology. 2022;93:71-83.
2.Hsu SY, Chen CH, Mukda S, Leu S. Neuronal Pnn Deficiency Increases Oxidative Stress and Exacerbates Cerebral Ischemia/Reperfusion Injury in Mice. Antioxidants (Basel). 2022;11(3).
3.Suwanjang W, Ruankham W, Chetsawang B, Mukda S, Ngampramuan S, Srisung S, et al. Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats. Neurochem Int. 2021;148:105083.
4.Veschsanit N, Yang JL, Ngampramuan S, Viwatpinyo K, Pinyomahakul J, Lwin T, Chancharoen, P, Rungruang, S, Govitrapong, P, Mukda, S. Melatonin reverts methamphetamine-induced learning and memory impairments and hippocampal alterations in mice. Life Sci. 2021;265:118844.
5.Lwin T, Yang JL, Ngampramuan S, Viwatpinyo K, Chancharoen P, Veschsanit N, Pinyomahakul J, Govitrapong P, Mukda, S. Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFkappaB signaling pathway in the mouse hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110109.
6.Hsu SY, Mukda S, Leu S. Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation. Brain Sci. 2020;10(10):708.
7.Yang JL, Chen WY, Mukda S, Yang YR, Sun SF, Chen SD. Oxidative DNA damage is concurrently repaired by base excision repair (BER) and apyrimidinic endonuclease 1 (APE1)-initiated nonhomologous end joining (NHEJ) in cortical neurons. Neuropathol Appl Neurobiol. 2020;46(4):375-90.
8.Hein ZM, Kraiwattanapirom N, Mukda S, Chetsawang B. The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin. J Neuroimmunol. 2020;344:577232.
9.Mukda S, Tsai CY, Leu S, Yang JL, Chan SHH. Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions. J Biomed Sci. 2019;26(1):43.
10.Rangphueng J, Kongkachuichai R, Mukda S, Sirivarasai J, Sae-chew P, Srisala S, et al. Effects of alcoholic extracts of sweet-fruited tamarind (Tamarindus indica L.) and banana (Musa sapientum L.) on Hydrogen peroxide-induced cytotoxicity in Human Neuroblastoma SH-SY5Y cells. Thai J Toxicol. 2018;32(2):63-81.
11.Yang JL, Mukda S, Chen SD. Diverse roles of mitochondria in ischemic stroke. Redox Biol. 2018;16:263-75.
12.Permpoonputtana K, Tangweerasing P, Mukda S, Boontem P, Nopparat C, Govitrapong P. Long-term administration of melatonin attenuates neuroinflammation in the aged mouse brain. EXCLI J. 2018;17:634-46.
13.Ngampramuan S, Tungtong P, Mukda S, Jariyavilas A, Sakulisariyaporn C. Evaluation of Autonomic Nervous System, Saliva Cortisol Levels, and Cognitive Function in Major Depressive Disorder Patients. Depress Res Treat. 2018;2018:7343592.
14.Jenwitheesuk A, Park S, Wongchitrat P, Tocharus J, Mukda S, Shimokawa I, et al. Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. Neurochem Res. 2018;43(1):144-52.
15.Jenwitheesuk A, Boontem P, Wongchitrat P, Tocharus J, Mukda S, Govitrapong P. Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway. EXCLI J. 2017;16:340-53.
16.Chetsawang J, Mukda S, Srimokra R, Govitrapong P, Chetsawang B. Role of Melatonin in Reducing Amphetamine-Induced Degeneration in Substantia Nigra of Rats via Calpain and Calpastatin Interaction. J Exp Neurosci. 2017;11:1179069517719237.
17.Wongchitrat P, Lansubsakul N, Kamsrijai U, Sae-Ung K, Mukda S, Govitrapong P. Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis. Neurochem Int. 2016;100:97-109.
18.Thangnipon W, Puangmalai N, Suwanna N, Soi-Ampornkul R, Phonchai R, Kotchabhakdi N, Mukda S, et al. Potential role of N-benzylcinnamide in inducing neuronal differentiation from human amniotic fluid mesenchymal stem cells. Neurosci Lett. 2016;610:6-12.
19.Mukda S, Panmanee J, Boontem P, Govitrapong P. Melatonin administration reverses the alteration of amyloid precursor protein-cleaving secretases expression in aged mouse hippocampus. Neurosci Lett. 2016;621:39-46.
20.Krityakiarana W, Sompup K, Jongkamonwiwat N, Mukda S, Pinilla FG, Govitrapong P, et al. Effects of melatonin on severe crush spinal cord injury-induced reactive astrocyte and scar formation. J Neurosci Res. 2016;94(12):1451-9.
21.Singhakumar R, Boontem P, Ekthuwapranee K, Sotthibundhu A, Mukda S, Chetsawang B, et al. Melatonin attenuates methamphetamine-induced inhibition of neurogenesis in the adult mouse hippocampus: An in vivo study. Neurosci Lett. 2015;606:209-14.
22.Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, et al. Melatonin regulates the transcription of betaAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. J Pineal Res. 2015;59(3):308-20.
23.Tipyasang R, Kunwittaya S, Mukda S, Kotchabhakdi NJ, Kotchabhakdi N. Enriched environment attenuates changes in water-maze performance and BDNF level caused by prenatal alcohol exposure. EXCLI J. 2014;13:536-47.
24.Jenwitheesuk A, Nopparat C, Mukda S, Wongchitrat P, Govitrapong P. Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci. 2014;15(9):16848-84.
25.Wongchitrat P, Mukda S, Phansuwan-Pujito P, Govitrapong P. Effect of amphetamine on the clock gene expression in rat striatum. Neurosci Lett. 2013;542:126-30.
26.Permpoonputtana K, Mukda S, Govitrapong P. Effect of melatonin on D-amphetamine-induced neuroglial alterations in postnatal rat hippocampus and prefrontal cortex. Neurosci Lett. 2012;524(1):1-4.
27.Mukda S, Vimolratana O, Govitrapong P. Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum. Neurosci Lett. 2011;488(2):154-7.
28.Mukda S, Moller M, Ebadi M, Govitrapong P. The modulatory effect of substance P on rat pineal norepinephrine release and melatonin secretion. Neurosci Lett. 2009;461(3):258-61.
29.Mukda S, Kaewsuk S, Ebadi M, Govitrapong P. Amphetamine-induced changes in dopamine receptors in early postnatal rat brain. Dev Neurosci. 2009;31(3):193-201.
30.Kongsuphol P, Mukda S, Nopparat C, Villarroel A, Govitrapong P. Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J Pineal Res. 2009;46(2):199-206.
31.Mukda S, Chetsawang B, Govitrapong P, Schmidt PT, Hay-Schmidt A, Moller M. Tachykinins and tachykinin-receptors in the rat pineal gland. Eur J Neurosci. 2005;21(10):2743-51.
32.Kim JS, Coon SL, Blackshaw S, Cepko CL, Moller M, Mukda S, et al. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. J Biol Chem. 2005;280(1):677-84.
33.Gaildrat P, Moller M, Mukda S, Humphries A, Carter DA, Ganapathy V, et al. A novel pineal-specific product of the oligopeptide transporter PepT1 gene: circadian expression mediated by cAMP activation of an intronic promoter. J Biol Chem. 2005;280(17):16851-60.
34.Phansuwan-Pujito P, Saleema L, Mukda S, Tongjaroenbuangam W, Jutapakdeegul N, Casalotti SO, et al. The opioid receptors in inner ear of different stages of postnatal rats. Hear Res. 2003;184(1-2):1-10.
35.Govitrapong P, Mukda S, Turakitwanakan W, Dumrongphol H, Chindaduangratn C, Sanvarinda Y. Platelet serotonin transporter in schizophrenic patients with and without neuroleptic treatment. Neurochem Int. 2002;41(4):209-16.