Our Protein Structure and Proteomics (PSP) Laboratory has a long interest in research to elucidate structural conformation and functional mechanism of insect larvicidal proteins derived from Bacillus thruringiensis. We have applied spectroscopic and biophysical techniques to trace conformational transition and interaction of the mosquitocidal Cry4Ba and Cyt2Aa proteins. Mutant proteins were then designed and constructed for stability and activity enhancement.
