{"id":762,"date":"2025-06-19T22:14:23","date_gmt":"2025-06-19T15:14:23","guid":{"rendered":"https:\/\/mb-dev.mahidol.ac.th\/mumb\/?page_id=762"},"modified":"2026-03-04T10:47:08","modified_gmt":"2026-03-04T03:47:08","slug":"jiraporn-profile","status":"publish","type":"page","link":"https:\/\/mb.mahidol.ac.th\/th\/jiraporn-profile\/","title":{"rendered":"jiraporn-profile"},"content":{"rendered":"\n

\u0e14\u0e23.\u0e08\u0e34\u0e23\u0e32\u0e1e\u0e23 \u0e1b\u0e32\u0e19\u0e21\u0e13\u0e35
\u0e1c\u0e39\u0e49\u0e0a\u0e48\u0e27\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e32\u0e08\u0e32\u0e23\u0e22\u0e4c<\/span>\u00a0\u2003<\/span><\/p><\/div><\/div><\/div>\n\n\n\n

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\"Jiraporn<\/a><\/div>

Jiraporn Panmanee, Ph.D.<\/h1>

Assistant Professor<\/h4>

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<\/i> Computational analyses, e.g., virtual screening, molecular docking in conjunction with cellular and proteomics studies are exploited for investigating pesticide-related neurotoxicity and developing a new class of pesticides. <\/span><\/i><\/span><\/p><\/blockquote>\n\n\n\n

<\/div>\n\n\n\n

Tel: 66 (0) 2441-9003 \u2013 7 Ext. 1437
Email: jiraporn.pammahidol.ac.th
Ph.D. (Biological Sciences), University of Liverpool, United Kingdom
Academic Program(s)
Neuroscience<\/a>
Molecular and Integrative Biosciences<\/a><\/p><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n

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Research Summary<\/span>\u00a0\u2003<\/span><\/p><\/div><\/div><\/div>\n\n\n\n

My research focuses on elucidating the molecular mechanisms underlying neurodegenerative diseases like Alzheimer\u2019s, with a keen interest in how environmental factors, particularly pesticides, impact neurotoxicity and brain health. Leveraging computational modeling, cell-based assays, and proteomics, I seek to uncover pathways that contribute to neuronal degeneration and resilience. Integrating these insights with structural biology, I aim to identify and design small molecules that target critical proteins, advancing drug discovery efforts for neurological disorders.

Research Interest<\/strong>
– Aging and Alzheimer\u2019s disease
– Neurotoxicity of commonly used pesticides
– Structure-based drug discovery
– Computer-aided drug design

Current Research Projects<\/strong>
– Small molecule drug discovery targeting natural compounds for Alzheimer\u2019s disease
– Design and development of small molecule inhibitors targeting indoleamine 2 ,3 -dioxygenase 1 (IDO-1) in the neuroinflammatory process for neurodegenerative disease therapeutics.
– Studies on the neurotoxicity and development of neurological diseases caused by agricultural pesticides of the organophosphate class.<\/p><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n

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Selected Publications<\/span>\u00a0\u2003<\/span><\/p><\/div><\/div><\/div>\n\n\n\n

1.Panmanee J<\/strong>, Charoensutthivarakul S, Cheng CW, Promthep K, Mukda S, Prasertporn T, Nopparat C, Teerapo K, Supcharoen P, Petchyam N, Chetsawang B, Govitrapong P, Phanchana M. A Complex Interplay Between Melatonin and ROR\u03b2: ROR\u03b2 is Unlikely a Putative Receptor for Melatonin as Revealed by Biophysical Assays. Mol Neurobiol. 2025.

2.Panmanee J<\/strong>, Phanchana M, Pearngam P, Petchyam N, Promthep K, Wisomka P, Kutpruek S, Pannengpetch S, Prasertporn T, Mukda S, Govitrapong P, Nopparat C. A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous \u03b2-amyloid-42 Induced Mitochondrial Impairment, Intracellular \u03b2-amyloid Accumulation and Tau Hyperphosphorylation in Human SH-SY5Y Cells. Cell Biol Int. 2025 Jun;49(6):659-673.

3.Promthep K, Nopparat C, Mukda S, Pannengpetch S, Wisomka P, Chantadul V, Phanchana M,\u00a0Panmanee J*<\/strong>. Proteomic profiling reveals neuronal ion channel dysregulation and cellular responses to DNA damage-induced cell cycle arrest and senescence in human neuroblastoma SH-SY5Y cells exposed to cypermethrin. Neurotoxicology. 2022

4.Panmanee J<\/strong>, Bradley-Clarke J, Mato JM, O\u2019Neill PM, Antonyuk SV, Hasnain SS. Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory \u03b2 subunit and quinolone-based compounds. FEBS J. 2019 Jun;286(11):2135-2154.

5.Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, Vincent B, Govitrapong P. Melatonin regulates the transcription of \u03b2APP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. J Pineal Res. 2015<\/p><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n

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