{"id":5504,"date":"2025-07-23T09:06:14","date_gmt":"2025-07-23T02:06:14","guid":{"rendered":"https:\/\/mb-dev.mahidol.ac.th\/mumb\/?p=5504"},"modified":"2026-03-05T16:08:48","modified_gmt":"2026-03-05T09:08:48","slug":"reproductive-dysfunction","status":"publish","type":"post","link":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/","title":{"rendered":"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients"},"content":{"rendered":"\n<div class=\"wp-block-essential-blocks-wrapper alignfull  root-eb-wrapper-hi0ah\"><div class=\"eb-parent-wrapper eb-parent-eb-wrapper-hi0ah \"><div class=\"eb-wrapper-outer eb-wrapper-hi0ah\"><div class=\"eb-wrapper-inner\"><div class=\"eb-wrapper-inner-blocks eb-wrapper-align-center\">\n<div class=\"wp-block-essential-blocks-advanced-heading  root-eb-advance-heading-wenlp\"><div class=\"eb-parent-wrapper eb-parent-eb-advance-heading-wenlp \"><div class=\"eb-advance-heading-wrapper eb-advance-heading-wenlp button-1 undefined\" data-id=\"eb-advance-heading-wenlp\"><h2 class=\"eb-ah-title\"><span class=\"first-title\">Research Highlights<\/span><\/h2><\/div><\/div><\/div>\n\n\n\n\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-wrapper alignfull  root-eb-wrapper-tjfz6\"><div class=\"eb-parent-wrapper eb-parent-eb-wrapper-tjfz6 \"><div class=\"eb-wrapper-outer eb-wrapper-tjfz6\"><div class=\"eb-wrapper-inner\"><div class=\"eb-wrapper-inner-blocks eb-wrapper-align-center\">\n<div class=\"wp-block-essential-blocks-advanced-image  root-eb-advanced-image-rsw39\"><div class=\"eb-parent-wrapper eb-parent-eb-advanced-image-rsw39 \"><figure class=\"eb-advanced-image-wrapper eb-advanced-image-rsw39 no-effect\" data-id=\"eb-advanced-image-rsw39\"><div class=\"eb-image-wrapper\"><div class=\"eb-image-wrapper-inner eb-img-style-square\"><img decoding=\"async\" src=\"https:\/\/mb-dev.mahidol.ac.th\/mumb\/wp-content\/uploads\/2025\/07\/Reproductive-banner.png\" alt=\"\"\/><\/div><\/div><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-text  root-eb-text-7t9en\"><div class=\"eb-parent-wrapper eb-parent-eb-text-7t9en \"><div class=\"eb-text-wrapper eb-text-7t9en\" data-id=\"eb-text-7t9en\"><p class=\"eb-text\"><strong>Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients<\/strong><br><br>Heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice derived from C57BL\/6 wild-type (WT) mice have phenotypic of \u03b2-thalassemia (BT) and have been widely used for studying this disease except reproductive disorders. The present study determined whether male BKO mice recapitulate reproductive problems as BT men. Mice were randomly assigned into groups depending on the genotype (WT vs. BKO) and intervention (control vs. iron-loaded). Euthanized mice were collected blood, testes, epididymides, hypothalamus, and anterior pituitary for assessing hematological parameters, plasma iron and testosterone levels, testis iron levels, sperm characteristics, and histological alterations. Iron administration caused significant increases of plasma and testis iron levels (p\u2009&lt;\u20090.001) but had no significant influence on the hematological profile of BKO mice, which indeed had fewer erythrocyte, hemoglobin, and hematocrit but had greater reticulocyte than WT (p\u2009&lt;\u20090.001 to p\u2009=\u20090.017).<\/p><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-advanced-image  root-eb-advanced-image-54v9v\"><div class=\"eb-parent-wrapper eb-parent-eb-advanced-image-54v9v \"><figure class=\"eb-advanced-image-wrapper eb-advanced-image-54v9v no-effect\" data-id=\"eb-advanced-image-54v9v\"><div class=\"eb-image-wrapper\"><div class=\"eb-image-wrapper-inner eb-img-style-square\"><img decoding=\"async\" src=\"https:\/\/mb-dev.mahidol.ac.th\/mumb\/wp-content\/uploads\/2025\/07\/Reproductive_Fig6.webp\" alt=\"\"\/><\/div><\/div><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-text  root-eb-text-yhltg\"><div class=\"eb-parent-wrapper eb-parent-eb-text-yhltg \"><div class=\"eb-text-wrapper eb-text-yhltg\" data-id=\"eb-text-yhltg\"><p class=\"eb-text\">Furthermore, irrespective of the genotype, iron administration decreased plasma testosterone levels (p\u2009=\u20090.03 to p\u2009>\u20090.05), total sperm count (p\u2009&lt;\u20090.001), and percent normal sperm morphology (p\u2009\u2264\u20090.01). Based on Perls\u2019 Prussian blue staining, excess iron was ubiquitously present in the anterior pituitary and testicular interstitium of iron-loaded mice. This mineral, however, caused no significant changes in reproductive organs microstructure as visualized by hematoxylin and eosin staining. In conclusion, besides physiological dysfunction of many organ systems, iron-loaded male BKO mice exhibit reproductive problems and abnormal sperm characteristics similar to BT men. Therefore, this animal model seems invaluable for future biomedical research involved in various aspects of BT-related male reproductive disorders.<\/p><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-button  root-eb-button-9iafa\"><div class=\"eb-parent-wrapper eb-parent-eb-button-9iafa \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-9iafa\"><div class=\"eb-button\"><div class=\"eb-button-inner-wrapper \"><a class=\"eb-button-anchor  \" href=\"https:\/\/www.nature.com\/articles\/s41598-025-87619-y\" rel=\"noopener\">Read the full article <\/a><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n<div class=\"pvc_clear\"><\/div><p id=\"pvc_stats_5504\" class=\"pvc_stats total_only  \" data-element-id=\"5504\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p><div class=\"pvc_clear\"><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":5501,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","_eb_data_table":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[15],"tags":[],"class_list":["post-5504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight-new"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients - Institute of Molecular Biosciences<\/title>\r\n<meta name=\"description\" content=\"\u0e07\u0e32\u0e19\u0e27\u0e34\u0e08\u0e31\u0e22\u0e2a\u0e16\u0e32\u0e1a\u0e31\u0e19\u0e0a\u0e35\u0e27\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e42\u0e21\u0e40\u0e25\u0e01\u0e38\u0e25 \u0e21.\u0e21\u0e2b\u0e34\u0e14\u0e25 \u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e1c\u0e34\u0e14\u0e1b\u0e01\u0e15\u0e34\u0e02\u0e2d\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e2a\u0e37\u0e1a\u0e1e\u0e31\u0e19\u0e18\u0e38\u0e4c\u0e41\u0e25\u0e30\u0e04\u0e38\u0e13\u0e20\u0e32\u0e1e\u0e2d\u0e2a\u0e38\u0e08\u0e34\u0e43\u0e19\u0e2b\u0e19\u0e39\u0e17\u0e14\u0e25\u0e2d\u0e07\u0e18\u0e32\u0e25\u0e31\u0e2a\u0e0b\u0e35\u0e40\u0e21\u0e35\u0e22\u0e17\u0e35\u0e48\u0e21\u0e35\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2b\u0e25\u0e47\u0e01\u0e40\u0e01\u0e34\u0e19 \u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e40\u0e1b\u0e47\u0e19\u0e42\u0e21\u0e40\u0e14\u0e25\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e0a\u0e32\u0e22\" \/>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients - Institute of Molecular Biosciences\" \/>\r\n<meta property=\"og:description\" content=\"\u0e07\u0e32\u0e19\u0e27\u0e34\u0e08\u0e31\u0e22\u0e2a\u0e16\u0e32\u0e1a\u0e31\u0e19\u0e0a\u0e35\u0e27\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e42\u0e21\u0e40\u0e25\u0e01\u0e38\u0e25 \u0e21.\u0e21\u0e2b\u0e34\u0e14\u0e25 \u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e1c\u0e34\u0e14\u0e1b\u0e01\u0e15\u0e34\u0e02\u0e2d\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e2a\u0e37\u0e1a\u0e1e\u0e31\u0e19\u0e18\u0e38\u0e4c\u0e41\u0e25\u0e30\u0e04\u0e38\u0e13\u0e20\u0e32\u0e1e\u0e2d\u0e2a\u0e38\u0e08\u0e34\u0e43\u0e19\u0e2b\u0e19\u0e39\u0e17\u0e14\u0e25\u0e2d\u0e07\u0e18\u0e32\u0e25\u0e31\u0e2a\u0e0b\u0e35\u0e40\u0e21\u0e35\u0e22\u0e17\u0e35\u0e48\u0e21\u0e35\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2b\u0e25\u0e47\u0e01\u0e40\u0e01\u0e34\u0e19 \u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e40\u0e1b\u0e47\u0e19\u0e42\u0e21\u0e40\u0e14\u0e25\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e0a\u0e32\u0e22\" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/\" \/>\r\n<meta property=\"og:site_name\" content=\"Institute of Molecular Biosciences\" \/>\r\n<meta property=\"article:published_time\" content=\"2025-07-23T02:06:14+00:00\" \/>\r\n<meta property=\"article:modified_time\" content=\"2026-03-05T09:08:48+00:00\" \/>\r\n<meta property=\"og:image\" content=\"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/07\/Reproductive-banner.png\" \/>\r\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\r\n\t<meta property=\"og:image:height\" content=\"911\" \/>\r\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\r\n<meta name=\"author\" content=\"admin\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#\\\/schema\\\/person\\\/9fce9d7cde09a51141a969ba25ef59bd\"},\"headline\":\"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients\",\"datePublished\":\"2025-07-23T02:06:14+00:00\",\"dateModified\":\"2026-03-05T09:08:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/\"},\"wordCount\":285,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Reproductive-banner-e1773998109822.png\",\"articleSection\":[\"research-highlight-new\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/\",\"url\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/\",\"name\":\"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients - Institute of Molecular Biosciences\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Reproductive-banner-e1773998109822.png\",\"datePublished\":\"2025-07-23T02:06:14+00:00\",\"dateModified\":\"2026-03-05T09:08:48+00:00\",\"description\":\"\u0e07\u0e32\u0e19\u0e27\u0e34\u0e08\u0e31\u0e22\u0e2a\u0e16\u0e32\u0e1a\u0e31\u0e19\u0e0a\u0e35\u0e27\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e42\u0e21\u0e40\u0e25\u0e01\u0e38\u0e25 \u0e21.\u0e21\u0e2b\u0e34\u0e14\u0e25 \u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e1c\u0e34\u0e14\u0e1b\u0e01\u0e15\u0e34\u0e02\u0e2d\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e2a\u0e37\u0e1a\u0e1e\u0e31\u0e19\u0e18\u0e38\u0e4c\u0e41\u0e25\u0e30\u0e04\u0e38\u0e13\u0e20\u0e32\u0e1e\u0e2d\u0e2a\u0e38\u0e08\u0e34\u0e43\u0e19\u0e2b\u0e19\u0e39\u0e17\u0e14\u0e25\u0e2d\u0e07\u0e18\u0e32\u0e25\u0e31\u0e2a\u0e0b\u0e35\u0e40\u0e21\u0e35\u0e22\u0e17\u0e35\u0e48\u0e21\u0e35\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2b\u0e25\u0e47\u0e01\u0e40\u0e01\u0e34\u0e19 \u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e40\u0e1b\u0e47\u0e19\u0e42\u0e21\u0e40\u0e14\u0e25\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e0a\u0e32\u0e22\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#primaryimage\",\"url\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Reproductive-banner-e1773998109822.png\",\"contentUrl\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/Reproductive-banner-e1773998109822.png\",\"width\":1024,\"height\":364},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/reproductive-dysfunction\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#website\",\"url\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/\",\"name\":\"Institute of Molecular Biosciences\",\"description\":\"Mahidol University\",\"publisher\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#organization\",\"name\":\"Institute of Molecular Biosciences\",\"url\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/mb_logo-th-e1773998185551.png\",\"contentUrl\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/mb_logo-th-e1773998185551.png\",\"width\":1024,\"height\":273,\"caption\":\"Institute of Molecular Biosciences\"},\"image\":{\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/#\\\/schema\\\/person\\\/9fce9d7cde09a51141a969ba25ef59bd\",\"name\":\"admin\",\"sameAs\":[\"https:\\\/\\\/mb.mahidol.ac.th\"],\"url\":\"https:\\\/\\\/mb.mahidol.ac.th\\\/th\\\/author\\\/admin\\\/\"}]}<\/script>\r\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients - Institute of Molecular Biosciences","description":"\u0e07\u0e32\u0e19\u0e27\u0e34\u0e08\u0e31\u0e22\u0e2a\u0e16\u0e32\u0e1a\u0e31\u0e19\u0e0a\u0e35\u0e27\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e42\u0e21\u0e40\u0e25\u0e01\u0e38\u0e25 \u0e21.\u0e21\u0e2b\u0e34\u0e14\u0e25 \u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e1c\u0e34\u0e14\u0e1b\u0e01\u0e15\u0e34\u0e02\u0e2d\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e2a\u0e37\u0e1a\u0e1e\u0e31\u0e19\u0e18\u0e38\u0e4c\u0e41\u0e25\u0e30\u0e04\u0e38\u0e13\u0e20\u0e32\u0e1e\u0e2d\u0e2a\u0e38\u0e08\u0e34\u0e43\u0e19\u0e2b\u0e19\u0e39\u0e17\u0e14\u0e25\u0e2d\u0e07\u0e18\u0e32\u0e25\u0e31\u0e2a\u0e0b\u0e35\u0e40\u0e21\u0e35\u0e22\u0e17\u0e35\u0e48\u0e21\u0e35\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2b\u0e25\u0e47\u0e01\u0e40\u0e01\u0e34\u0e19 \u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e40\u0e1b\u0e47\u0e19\u0e42\u0e21\u0e40\u0e14\u0e25\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e0a\u0e32\u0e22","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/","og_locale":"en_US","og_type":"article","og_title":"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients - Institute of Molecular Biosciences","og_description":"\u0e07\u0e32\u0e19\u0e27\u0e34\u0e08\u0e31\u0e22\u0e2a\u0e16\u0e32\u0e1a\u0e31\u0e19\u0e0a\u0e35\u0e27\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e42\u0e21\u0e40\u0e25\u0e01\u0e38\u0e25 \u0e21.\u0e21\u0e2b\u0e34\u0e14\u0e25 \u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e1c\u0e34\u0e14\u0e1b\u0e01\u0e15\u0e34\u0e02\u0e2d\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e2a\u0e37\u0e1a\u0e1e\u0e31\u0e19\u0e18\u0e38\u0e4c\u0e41\u0e25\u0e30\u0e04\u0e38\u0e13\u0e20\u0e32\u0e1e\u0e2d\u0e2a\u0e38\u0e08\u0e34\u0e43\u0e19\u0e2b\u0e19\u0e39\u0e17\u0e14\u0e25\u0e2d\u0e07\u0e18\u0e32\u0e25\u0e31\u0e2a\u0e0b\u0e35\u0e40\u0e21\u0e35\u0e22\u0e17\u0e35\u0e48\u0e21\u0e35\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2b\u0e25\u0e47\u0e01\u0e40\u0e01\u0e34\u0e19 \u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e40\u0e1b\u0e47\u0e19\u0e42\u0e21\u0e40\u0e14\u0e25\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e0a\u0e32\u0e22","og_url":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/","og_site_name":"Institute of Molecular Biosciences","article_published_time":"2025-07-23T02:06:14+00:00","article_modified_time":"2026-03-05T09:08:48+00:00","og_image":[{"width":2560,"height":911,"url":"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/07\/Reproductive-banner.png","type":"image\/png"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#article","isPartOf":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/"},"author":{"name":"admin","@id":"https:\/\/mb.mahidol.ac.th\/th\/#\/schema\/person\/9fce9d7cde09a51141a969ba25ef59bd"},"headline":"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients","datePublished":"2025-07-23T02:06:14+00:00","dateModified":"2026-03-05T09:08:48+00:00","mainEntityOfPage":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/"},"wordCount":285,"commentCount":0,"publisher":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/#organization"},"image":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#primaryimage"},"thumbnailUrl":"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/07\/Reproductive-banner-e1773998109822.png","articleSection":["research-highlight-new"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/","url":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/","name":"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients - Institute of Molecular Biosciences","isPartOf":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/#website"},"primaryImageOfPage":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#primaryimage"},"image":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#primaryimage"},"thumbnailUrl":"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/07\/Reproductive-banner-e1773998109822.png","datePublished":"2025-07-23T02:06:14+00:00","dateModified":"2026-03-05T09:08:48+00:00","description":"\u0e07\u0e32\u0e19\u0e27\u0e34\u0e08\u0e31\u0e22\u0e2a\u0e16\u0e32\u0e1a\u0e31\u0e19\u0e0a\u0e35\u0e27\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e42\u0e21\u0e40\u0e25\u0e01\u0e38\u0e25 \u0e21.\u0e21\u0e2b\u0e34\u0e14\u0e25 \u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e1c\u0e34\u0e14\u0e1b\u0e01\u0e15\u0e34\u0e02\u0e2d\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e2a\u0e37\u0e1a\u0e1e\u0e31\u0e19\u0e18\u0e38\u0e4c\u0e41\u0e25\u0e30\u0e04\u0e38\u0e13\u0e20\u0e32\u0e1e\u0e2d\u0e2a\u0e38\u0e08\u0e34\u0e43\u0e19\u0e2b\u0e19\u0e39\u0e17\u0e14\u0e25\u0e2d\u0e07\u0e18\u0e32\u0e25\u0e31\u0e2a\u0e0b\u0e35\u0e40\u0e21\u0e35\u0e22\u0e17\u0e35\u0e48\u0e21\u0e35\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2b\u0e25\u0e47\u0e01\u0e40\u0e01\u0e34\u0e19 \u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e40\u0e1b\u0e47\u0e19\u0e42\u0e21\u0e40\u0e14\u0e25\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e0a\u0e32\u0e22","breadcrumb":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#primaryimage","url":"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/07\/Reproductive-banner-e1773998109822.png","contentUrl":"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/07\/Reproductive-banner-e1773998109822.png","width":1024,"height":364},{"@type":"BreadcrumbList","@id":"https:\/\/mb.mahidol.ac.th\/th\/reproductive-dysfunction\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mb.mahidol.ac.th\/th\/"},{"@type":"ListItem","position":2,"name":"Male reproductive phenotype alterations in heterozygous \u03b2-globin gene knockout thalassemia (BKO) mice as a model for \u03b2-thalassemia patients"}]},{"@type":"WebSite","@id":"https:\/\/mb.mahidol.ac.th\/th\/#website","url":"https:\/\/mb.mahidol.ac.th\/th\/","name":"Institute of Molecular Biosciences","description":"Mahidol University","publisher":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mb.mahidol.ac.th\/th\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/mb.mahidol.ac.th\/th\/#organization","name":"Institute of Molecular Biosciences","url":"https:\/\/mb.mahidol.ac.th\/th\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/mb.mahidol.ac.th\/th\/#\/schema\/logo\/image\/","url":"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/09\/mb_logo-th-e1773998185551.png","contentUrl":"https:\/\/mb.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/09\/mb_logo-th-e1773998185551.png","width":1024,"height":273,"caption":"Institute of Molecular Biosciences"},"image":{"@id":"https:\/\/mb.mahidol.ac.th\/th\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/mb.mahidol.ac.th\/th\/#\/schema\/person\/9fce9d7cde09a51141a969ba25ef59bd","name":"admin","sameAs":["https:\/\/mb.mahidol.ac.th"],"url":"https:\/\/mb.mahidol.ac.th\/th\/author\/admin\/"}]}},"publishpress_future_action":{"enabled":false,"date":"2026-04-12 00:06:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/posts\/5504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/comments?post=5504"}],"version-history":[{"count":1,"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/posts\/5504\/revisions"}],"predecessor-version":[{"id":14266,"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/posts\/5504\/revisions\/14266"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/media\/5501"}],"wp:attachment":[{"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/media?parent=5504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/categories?post=5504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mb.mahidol.ac.th\/th\/wp-json\/wp\/v2\/tags?post=5504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}