{"id":9193,"date":"2025-09-22T10:30:52","date_gmt":"2025-09-22T03:30:52","guid":{"rendered":"https:\/\/mb.mahidol.ac.th\/th\/?p=9193"},"modified":"2026-03-17T13:01:42","modified_gmt":"2026-03-17T06:01:42","slug":"sh-sy5y-cells","status":"publish","type":"post","link":"https:\/\/mb.mahidol.ac.th\/th\/sh-sy5y-cells\/","title":{"rendered":"Dimethoate: Silent Trigger of Cellular Aging"},"content":{"rendered":"\n<div class=\"wp-block-essential-blocks-wrapper alignfull  root-eb-wrapper-hi0ah\"><div class=\"eb-parent-wrapper eb-parent-eb-wrapper-hi0ah \"><div class=\"eb-wrapper-outer eb-wrapper-hi0ah\"><div class=\"eb-wrapper-inner\"><div class=\"eb-wrapper-inner-blocks eb-wrapper-align-center\">\n<div class=\"wp-block-essential-blocks-advanced-heading  root-eb-advance-heading-wenlp\"><div class=\"eb-parent-wrapper eb-parent-eb-advance-heading-wenlp \"><div class=\"eb-advance-heading-wrapper eb-advance-heading-wenlp button-1 undefined\" data-id=\"eb-advance-heading-wenlp\"><h2 class=\"eb-ah-title\"><span class=\"first-title\">Research Highlights<\/span><\/h2><\/div><\/div><\/div>\n\n\n\n\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-wrapper alignfull  root-eb-wrapper-tjfz6\"><div class=\"eb-parent-wrapper eb-parent-eb-wrapper-tjfz6 \"><div class=\"eb-wrapper-outer eb-wrapper-tjfz6\"><div class=\"eb-wrapper-inner\"><div class=\"eb-wrapper-inner-blocks eb-wrapper-align-center\">\n<div class=\"wp-block-essential-blocks-advanced-image  root-eb-advanced-image-54v9v\"><div class=\"eb-parent-wrapper eb-parent-eb-advanced-image-54v9v \"><figure class=\"eb-advanced-image-wrapper eb-advanced-image-54v9v no-effect\" data-id=\"eb-advanced-image-54v9v\"><div class=\"eb-image-wrapper\"><div class=\"eb-image-wrapper-inner eb-img-style-square\"><img decoding=\"async\" src=\"https:\/\/mb-dev.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/09\/Dimethoate-banner.png\" alt=\"\"\/><\/div><\/div><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-text  root-eb-text-7t9en\"><div class=\"eb-parent-wrapper eb-parent-eb-text-7t9en \"><div class=\"eb-text-wrapper eb-text-7t9en\" data-id=\"eb-text-7t9en\"><p class=\"eb-text\"><strong>Sublethal effects of dimethoate on energy metabolism and its link to cellular senescence due to impaired mitochondrial respiration and ATP production in SH-SY5Y cells<\/strong><br><br>Dimethoate (DM), a widely used organophosphate pesticide, induces significant alterations in mitochondrial-related proteomes of SH-SY5Y cells without directly affecting cell viability. After, cells were exposed to 100 \u03bcM DM for 48 h, proteomic analysis revealed that 27 proteins associated with cellular metabolism and mitochondrial function were notably altered, affecting pathways such as oxidative phosphorylation, electron transport chain, and ATP synthesis. At sublethal concentrations, DM reduced mitochondrial ATP production, oxygen consumption rates (OCR), basal and maximal respiration, while preserving spare respiratory capacity (SRC) and proton leak, indicating maintained mitochondrial membrane integrity.<\/p><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-advanced-image  root-eb-advanced-image-2yyme\"><div class=\"eb-parent-wrapper eb-parent-eb-advanced-image-2yyme \"><figure class=\"eb-advanced-image-wrapper eb-advanced-image-2yyme no-effect\" data-id=\"eb-advanced-image-2yyme\"><div class=\"eb-image-wrapper\"><div class=\"eb-image-wrapper-inner eb-img-style-square\"><img decoding=\"async\" src=\"https:\/\/mb-dev.mahidol.ac.th\/th\/wp-content\/uploads\/2025\/09\/Dimethoate-lab.jpg\" alt=\"\"\/><\/div><\/div><\/figure><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-text  root-eb-text-yhltg\"><div class=\"eb-parent-wrapper eb-parent-eb-text-yhltg \"><div class=\"eb-text-wrapper eb-text-yhltg\" data-id=\"eb-text-yhltg\"><p class=\"eb-text\">Despite this, DM exposure caused mitochondrial membrane depolarization and increased mitochondrial superoxide production. These mitochondrial alterations were accompanied by enhanced cellular senescence, marked by p53-independent p21 activation, p38 MAPK activation, increased senescence-associated \u03b2-galactosidase (SA-\u03b2-gal) activity, and disrupted cell cycle progression. Additionally, DM treatment led to upregulation of DNA damage response (DDR) proteins and downregulation of proteins involved in DNA repair and genome stability. Although early-stage apoptosis was observed, elevated Bcl-2 expression suggested a shift toward apoptosis resistance and senescence. DM also disrupted energy-sensing pathways by increasing AMPK subunit expression, yet suppressed autophagy, as indicated by decreased p-mTOR, p-Beclin-1, and LC3-II\/I ratios. Collectively, these findings highlight a complex interplay between mitochondrial dysfunction, cellular senescence, and survival mechanisms, suggesting potential long-term effects of DM exposure on cellular health and aging processes.<\/p><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-essential-blocks-button  root-eb-button-9iafa\"><div class=\"eb-parent-wrapper eb-parent-eb-button-9iafa \"><div class=\"eb-button-wrapper eb-button-alignment eb-button-9iafa\"><div class=\"eb-button\"><div class=\"eb-button-inner-wrapper \"><a class=\"eb-button-anchor  \" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0048357525002330?via%3Dihub\" rel=\"noopener\">Read the full article <\/a><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n<div class=\"pvc_clear\"><\/div><p id=\"pvc_stats_9193\" class=\"pvc_stats total_only  \" data-element-id=\"9193\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" 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