{"id":9200,"date":"2025-09-22T10:34:33","date_gmt":"2025-09-22T03:34:33","guid":{"rendered":"https:\/\/mb.mahidol.ac.th\/th\/?p=9200"},"modified":"2026-03-05T15:17:57","modified_gmt":"2026-03-05T08:17:57","slug":"sphingomyelins-in-mosquito","status":"publish","type":"post","link":"https:\/\/mb.mahidol.ac.th\/th\/sphingomyelins-in-mosquito\/","title":{"rendered":"Unveiling Lipid-Mediated Enhancement of Flavivirus Infection"},"content":{"rendered":"\n
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Research Highlights<\/span><\/h2><\/div><\/div><\/div>\n\n\n\n\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n
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Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses<\/strong>

Many flaviviruses with high pandemic potential are transmitted through mosquito bites. While mosquito saliva is essential for transmission and represents a promising pan-flaviviral target, there is a dearth of knowledge on salivary metabolic transmission enhancers. Here, we show that extracellular vesicle (EV)-derived sphingomyelins in mosquito saliva reconfigure the human cell lipidome to increase viral protein levels, boosting skin infection and enhancing transmission for flaviviruses.<\/p><\/div><\/div><\/div>\n\n\n\n

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Lipids within internalized mosquito EVs enhance infection in fibroblast and immune human primary cells for multiple flaviviruses. Mosquito EV lipids selectively increase viral translation by inhibiting infection-induced endoplasmic reticulum (ER)-associated degradation of viral proteins. Infection enhancement solely results from the sphingomyelins within salivary mosquito EVs that augment human cell sphingomyelin concentration. Finally, EV-lipid co-inoculation exacerbates disease severity in vivo in mouse transmission assays. By discovering and elucidating how metabolic components of mosquito saliva promote transmission of flaviviruses, our study unveils lipids as a new category of targets against vectored transmission.<\/p><\/div><\/div><\/div>\n\n\n\n

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