Assoc. Prof. Chalermporn Ongvarrasopone, Ph.D.

     Black tiger shrimp culture in Thailand and worldwide have encountered with several problems such as diseases and growth. To date, there is no effective treatment to prevent or cure viral infection in shrimp. Therefore, our research goal is to understand the molecular mechanism of the viral host interaction. Therefore, characterization of the viral derived miRNAs and cellular miRNAs that respond to virus infection especially white spot syndrome virus and their targets are currently under investigated. To elucidate how the yellow head virus enters and trafficking in the cells, the role of the Rab proteins are functionally characterized. In addition, we employ the RNA interference technology that targeting both viral genes and endogenous genes to combat viral diseases.

1.Nantapojd T, Panyim S, Ongvarrasopone C. Identification and expression of white spot syndrome virus-encoded microRNAs in infected Penaeus monodon. Aquaculture. 2019;503:436-45.

2.Posiri P, Thongsuksangcharoena S, Chaysri N, Panyim S, Ongvarrasopone C. PmEEA1, the early endosomal protein is employed by YHV for successful infection in Penaeus monodon. Fish and Shellfish Immunology 2019;95:449-455.

3.Posiri P, Panyim S, Ongvarrasopone C. Rab5, an early endosomal protein required for yellow head virus infection of Penaeus monodon. Aquaculture. 2016; 459:43-53.

4.Posiri, P., Ongvarrasopone, C., Panyim S. (2013) A simple one-step method for producing dsRNA from E.coli to inhibit shrimp virus replication. J Virol Met. 188;64-69.

5.Ongvarrasopone, C., Chanasakulniyom, M., Sritumyalucksana, K., Panyim, S. (2008) Suppression of PmRab7 by dsRNA inhibits WSSV or YHV infection in shrimp. Mar Biotechnol (NY). 10(4):374-81.