Burkholderia pseudomallei is an intracellular bacterium that causes melioidosis, a severe disease in humans and animals that is endemic in Northeast Thailand, which is an emerging infectious disease and is the third most common cause of death from infectious diseases after HIV/AIDS and tuberculosis. This bacterium causes community-acquired bacteraemia with an average mortality rate of around 40%. This pathogen is resistant to common antibiotics and a suitable vaccine is not available. Hence, our research aims at understanding B. pseudomallei pathogenesis which is of key importance to gain insight into how B. pseudomallei hijack the host machinery for its intracellular life. This knowledge could be useful for the design of future novel vaccines and therapeutic approaches for melioidosis.

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