My research interests derive from this question: What the effects of long-term exposure to different classes of pesticides at a residual dose are, and whether the classical pesticides can interact with other cellular proteins apart from their commonly known targets. Currently, my main research focus is on the potential mechanism of neurodegeneration induced by pesticide exposure of the commonly used pesticides, e.g., organophosphates, carbamates and synthetic pyrethroids. At a residual dose, computational tools combining empirical cellular and proteomics studies are employed for studying their neurotoxicity in various aspects from acute cellular responses to long-term neurotoxicity. Furthermore, my future aim is to develop a new class of pesticides with less neurotoxicity by repurposing any compounds that may adopt pesticidal properties using structure-based design, virtual screening and activity tests.

1.Mukda S, Panmanee J, Boontem P, Govitrapong P. Melatonin administration reverses the alteration of amyloid precursor protein-cleaving secretases expression in aged mouse hippocampus. Neuroscience letters. 2016;621:39-46.

2.Panmanee J, Antonyuk SV, Hasnain SS. Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. Acta crystallographica Section D, Structural biology. 2020;76(Pt 6):594-607.

3.Panmanee J, Bradley-Clarke J, Mato JM, O’Neill PM, Antonyuk SV, Hasnain SS. Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds. The FEBS journal. 2019;286(11):2135-54.

4.Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, et al. Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. Journal of pineal research. 2015;59(3):308-20.