Assoc. Prof. Saovaros Svasti, Ph.D.

     Saovaros research interests are regulation of erythropoiesis and mechanism of ineffective erythropoiesis, novel therapy for thalassemia by antisense oligonucleotide and HbF inducer. She is also working on clinical complications of thalassemia including hypercoagulable states, infection and diabetes.

1.d’Arqom A, Nualkaew T, Jearawiriyapaisarn N, Kole R, Svasti S. Engineered U7 snRNA restores correct β-globin pre-mRNA splicing in mouse βIVS2-654-thalassemic erythroid progenitor cells. Hum Gene Ther. 2021;32(9-10):473-480.

2.Munkongdee T, Tongsima S, Ngamphiw C, Wangkumhang P, Peerapittayamongkol C, Hashim HB, Fucharoen S, Svasti S. Predictive SNPs for β0-thalassemia/HbE disease severity. Sci Rep. 2021;11(1):10352.

3.Nuamsee K, Chuprajob T, Pabuprapap W, Jintaridth P, Munkongdee T, Phannasil P, Vadolas J, Chaichompoo P, Suksamrarn A, Svasti S. Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at Gγ-globin gene promoter. Sci Rep. 2021;11(1):8552.

4.Nualkaew T, Jearawiriyapaisarn N, Hongeng S, Fucharoen S, Kole R, Svasti S. Restoration of correct βIVS2-654-globin mRNA splicing and HbA production by engineered U7 snRNA in β-thalassaemia/HbE erythroid cells. Sci Rep. 2019;9(1):7672.

5.Kheansaard W, Phongpao K, Paiboonsukwong K, Pattanapanyasat K, Chaichompoo P, Svasti S. Microparticles from β-thalassaemia/HbE patients induce endothelial cell dysfunction. Sci Rep. 2018;8(1):13033.