Mosquito-borne viruses such as dengue virus, Japanese encephalitis virus, Chikungunya virus and Zika virus are important human pathogens. These viruses are highly prevalent in mosquito endemic areas and cause a significant public health problem in many countries including Thailand. A better understanding of the processes mediating viral transmission is therefore essential. In addition, effective vaccines and therapeutic treatments against these viruses require intensive development. During viral replication, viruses interact and exploit the host cellular machinery and metabolism to facilitate viral replication, assembly and to overcome host defensive responses. However, those underlying mechanisms have not been fully revealed. Therefore, our current research aims to investigate the factors mediating viral transmission and to try to understand the molecular mechanisms of virus-host interactions upon virus infection and replication. The uncovered insights in molecular mechanisms may help to develop new approaches for antiviral drug development. With a strong effort, our laboratory has a well-established a fundamental platform in molecular biology and virology that potentially support the future study of new emerging viruses in Thailand.

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