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Chutima Thepparit, Ph.D.

My research goal is to develop vaccine candidates against infectious diseases by using virology and molecular techniques in selecting and developing vaccine strains alongside basic research for the understanding of virus pathogenesis.

  • Tel: 66 (0) 2441-9003 – 7 Ext. 1469
  • Email: chutima.thpmahidol.ac.th
  • Ph.D. (Molecular Genetics and Genetic Engineering), Mahidol University, 2005
  • Academic Program(s)

     The primary focus of my research is on infectious diseases, specifically the emerging viruses causing economic and health problems in Thailand, which include dengue, Zika, and enterovirus 71, the causative agent of hand, foot, and mouth disease. In particular, I am most interested in the host-virus interaction, including the viral entry and host cell response to viral infection. This insight brings about a better understanding of virus pathogenesis providing further research direction on diagnosis, therapeutics, and vaccine development. Currently, this interest conveys to various projects in our laboratory, including the development of live-attenuated Zika vaccine candidates, the selection of virus strains for the development of vaccines against hand, foot, and mouth disease, and the study of an effect of pre-existing dengue immunity to Zika virus infection in non-human primates. Furthermore, with collaboration with Assoc. Prof. Dr. Chak Sangma from Kasetsart University, the research expands to the development of a biosensor for virus detection, intending to cover all research areas; diagnosis, treatment, and protection against infectious diseases.

1.Thepparit C, Khongwichit S, Ketsuwan K, Libsittikul S, Auewarakul P, Smith DR. Dengue virus requires apoptosis linked gene-2-interacting protein X (ALIX) for viral propagation. 2019. Virus Res. 261:65-71.

2.Tancharoen C, Sukjee W, Thepparit C, Jaimipuk T, Auewarakul P, Thitithanyanont A, Sangma C. Electrochemical biosensor based on surface imprinting for zika virus detection in Serum. 2019. ACS Sens. 25;4(1):69-75.

3.Kanokudom S, Vilaivan T, Wikan N, Thepparit C, Smith DR, Assavalapsakul W. miR-21 promotes Dengue virus serotype 2 replication in HepG2 cells. 2017. Antiviral Res. 142:169-177.

4.Khongwichit S, Wikan N, Abere B, Thepparit C, Kuadkitkan A, Ubol S, Smith DR. Cell-type specific variation in the induction of ER stress and downstream events in chikungunya virus infection. 2016. Microb Pathog. 101:104-118.

5.Wongtrakul J, Paemanee A, Wintachai P, Thepparit C, Roytrakul S, Thongtan T, Janphen K, Supparatpinyo K, Smith DR. Nevirapine induces apoptosis in liver (HepG2) cells. 2016. Asian Pac J Trop Med. 9(6):547-53.

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