My research focuses on elucidating the molecular mechanisms underlying neurodegenerative diseases like Alzheimer’s, with a keen interest in how environmental factors, particularly pesticides, impact neurotoxicity and brain health. Leveraging computational modeling, cell-based assays, and proteomics, I seek to uncover pathways that contribute to neuronal degeneration and resilience. Integrating these insights with structural biology, I aim to identify and design small molecules that target critical proteins, advancing drug discovery efforts for neurological disorders.

Research Interest
-Aging and Alzheimer’s disease
-Neurotoxicity of commonly used pesticides
– Structure-based drug discovery
-Computer-aided drug design

Current Research Projects
-Small molecule drug discovery targeting natural compounds for Alzheimer’s disease
– Design and development of small molecule inhibitors targeting indoleamine 2 ,3 -dioxygenase 1 (IDO-1) in the neuroinflammatory process for neurodegenerative disease therapeutics.
– Studies on the neurotoxicity and development of neurological diseases caused by agricultural pesticides of the organophosphate class.

1.Panmanee J, Charoensutthivarakul S, Cheng CW, Promthep K, Mukda S, Prasertporn T, Nopparat C, Teerapo K, Supcharoen P, Petchyam N, Chetsawang B, Govitrapong P, Phanchana M. A Complex Interplay Between Melatonin and RORβ: RORβ is Unlikely a Putative Receptor for Melatonin as Revealed by Biophysical Assays. Mol Neurobiol. 2025

2.Panmanee J, Phanchana M, Pearngam P, Petchyam N, Promthep K, Wisomka P, Kutpruek S, Pannengpetch S, Prasertporn T, Mukda S, Govitrapong P, Nopparat C. A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous β-amyloid-42 Induced Mitochondrial Impairment, Intracellular β-amyloid Accumulation and Tau Hyperphosphorylation in Human SH-SY5Y Cells. Cell Biol Int. 2025 Jun;49(6):659-673.

3.Promthep K, Nopparat C, Mukda S, Pannengpetch S, Wisomka P, Chantadul V, Phanchana M, Panmanee J*. Proteomic profiling reveals neuronal ion channel dysregulation and cellular responses to DNA damage-induced cell cycle arrest and senescence in human neuroblastoma SH-SY5Y cells exposed to cypermethrin. Neurotoxicology. 2022

4.Panmanee J, Bradley-Clarke J, Mato JM, O’Neill PM, Antonyuk SV, Hasnain SS. Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds. FEBS J. 2019 Jun;286(11):2135-2154.

5.Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, Vincent B, Govitrapong P. Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells. J Pineal Res. 2015