Phattaraorn Havanapan, Ph.D.
Senior Researcher Level 2
The extracted peptides/proteins and their application will lead to possible use of a great biotechnological resource to develop peptide–based product for the treatment of microbial infection or boost innate immune response in various organisms.
Tel: 66 (0) 2441-9003 – 7 Ext. 1410
Email: phattaraorn.hav
mahidol.ac.th
Ph.D. (Molecular Genetics and Genetic Engineering), Mahidol University, 2007
Our works focus on proteomics and peptidomics in various organisms to novel studies for application. Our research is working on expression proteomics (proteome, phosphoproteome and glycoproteome) and peptidomics; functional proteins and antimicrobial peptides studies in several biological subjects by molecular techniques.We are also focusing on the comparative proteome profiling of plants (eg. para rubber tree) to identify and characterize immune-responsive proteins, antimicrobial proteins and peptides in several tissues including rubber latex and skim latex (waste) during microbial infection especially fungal infection in many economic plants.In addition, besides plant and its waste, we are focusing on crustacean (shrimp and crab) innate immunity via each hemocytes (blood cells) cell type after pathogen infection. Gel-based proteomics and proteomics-based approach are utilized to understand the roles of immune-related proteins and peptides in host defense mechanism response. We aim to discover the effective and sustainable way to protect the shrimps from pathogen infection especially viral infection.
1.Havanapan PO, Bourchookarn A, Ketterman A, Krittanai C. Comparative proteome analysis of rubber latex serum from pathogenic fungi tolerant and susceptible rubber tree (Hevea brasiliensis). J Proteomics. 2016;131:82-92.
2.Havanapan PO, Mangkalanan S, Phungthanom N, Krittanai C. Proteomic analysis and white spot syndrome virus interaction of mud crab (Scylla olivacea) revealed responsive roles of the hemocytes. Fish Shellfish Immunol. 2019; 89:458-467.
3.C. Yellow head virus infection in black tiger shrimp reveals specific interaction with granule-containing hemocytes and crustinPm1 as a responsive protein. Dev Comp Immunol. 2016;54:126-36.
4.Havanapan PO, Taengchaiyaphum S, Bourchookarn A, Ketterman A, Krittanai C. Yellow head virus binding to cell surface proteins from Penaeus monodon hemocytes. Fish Shellfish Immunol. 2014;41:126-36.
5.Havanapan PO, Thongboonkerd V. Are protease inhibitors required for gel-based proteomics of kidney and urine? J. Proteome Res. 2009; 8(6):3109-3117.
