Wasutorn Chankamngoen, Ph.D.
Senior Researcher Level 1
I investigate the mechanobiology of osteocytes through the application of advanced mechanical and microgravity simulations. This research aims to identify potent peptides for the development of novel therapeutic interventions targeting bone loss in astronauts and age-related osteoporosis.
Tel: 66 (0) 2441-9003 – 7 Ext. 1390
Email: wasutorn.cha@mahidol.ac.th
(Ph.D.) in Molecular Medicine Mahidol University, Thailand, 2022
My research focuses on understanding the fundamental mechanisms by which mechanical forces regulate cellular functions, with a particular emphasis on:
Osteocyte Biology: Investigating osteocytes, the most abundant cells in bone, which orchestrate numerous functions within bone and other tissues.
Space Biomedicine: Investigating the physiological impacts of microgravity to develop countermeasures for astronauts and translate these findings into therapies for age-related diseases on Earth.
Molecular Biology and Protein Engineering: Engineering novel protein-based therapeutics and developing scalable manufacturing processes to translate discoveries from the lab to the market.
Ultimately, my work seeks to translate fundamental insights from mechanobiology into tangible therapeutic solutions that address critical health challenges on Earth and in space.
1.Chankamngoen W, Thammayon N, Suntornsaratoon P, Nammultriputtar K, Kitiyanant N, Donpromma N, Chaichanan J, Supcharoen P, Teerapo K, Teerapornpuntakit J, Rodrat M, Panupinthu N, Svasti S, Wongdee K, Charoenphandhu N. Fibroblast growth factor-21 potentiates the stimulatory effects of 1,25-dihydroxyvitamin D3 on transepithelial calcium transport and TRPV6 Ca2+ channel expression. BBRC.2024 Nov 12; https://doi.org/10.1016/j.bbrc.2024.150429
2.Chankamngoen W, Krungchanuchat S, Thongbunchoo J, Sirinonthanawech N, Teerapornpuntakit J, Panupinthu N, Charoenphandhu N. Extracellular Fe2+ and Fe3+ modulate osteocytic viability, expression of SOST, RANKL and FGF23, and fluid flow-induced YAP1 nuclear translocation. Sci Rep. 2023 Dec 1;13(1):21173. doi: 10.1038/s41598-023-48436-3. PMID: 38040893; PMCID: PMC10692318.
3.Rodrat M, Wongdee K, Chankamngoen W, Teerapornpuntakit J, Thongbunchoo J, Tanramluk D, Charoenphandhu N. Modulation of fibroblast growth factor-23 expression and transepithelial calcium absorption in Caco-2 monolayer by calcium-sensing receptor and calcineurin under calcium hyperabsorptive state. Biochem Biophys Res Commun. 2023 Jun 4;659:105-112. doi: 10.1016/j.bbrc.2023.04.013. Epub 2023 Apr 7. PMID: 37060830.
4.Phummisutthigoon S, Lertsuwan K, Panupinthu N, Aeimlapa R, Teerapornpuntakit J, Chankamngoen W, Thongbunchoo J, Charoenphandhu N, Wongdee K. Fe3+ opposes the 1,25(OH)2D3-induced calcium transport across intestinal epithelium-like Caco-2 monolayer in the presence or absence of ascorbic acid. PLoS One. 2022 Aug 30;17(8):e0273267. doi: 10.1371/journal.pone.0273267. PMID: 36040915; PMCID: PMC9426938.
5.Chankamngoen W, Janvilisri T, Promdonkoy B, Boonserm P. In vitro analysis of the anticancer activity of Lysinibacillus sphaericus binary toxin in human cancer cell lines. 3 Biotech. 2020 Aug;10(8):365. doi: 10.1007/s13205-020-02361-8. Epub 2020 Jul 31. PMID: 32832326; PMCID: PMC7394974.
2019 Research Assistant Scholarship (Doctoral Degree) International Research Network (IRN), Thailand Science Research and Innovation (TSRI)
2016 Thailand Graduate Institute of Science and Technology (TGIST) National Science and Technology Development Agency (NSTDA)
