Mayuree Rodrat, Ph.D.
Senior Researcher Level 1
I study CFTR chloride and ion channels using advanced electrophysiology, alongside developing recombinant proteins and biologics to create innovative therapeutics with real-world healthcare impact.
Tel: 66 (0) 2441-9003 – 7 Ext. 1390
Email: mayuree.rod
mahidol.ac.th
Ph.D. (Physiology), Mahidol University, 2020
My research focuses on understanding the fundamental mechanisms that regulate cellular and physiological functions, with particular emphasis on:
- Calcium Metabolism – exploring the role of calcium in cellular signaling, ion homeostasis and systemic physiological regulation.
- Electrophysiology & Ion Transport – studying the function and regulation of ion channels and membrane transport systems in epithelial tissues, utilizing advanced electrophysiological techniques.
- Gastrointestinal and Respiratory Epithelial Physiology – examining the molecular regulation of ion and fluid transport in the digestive and respiratory systems, including testing small molecules and compounds on ion channels such as CFTR and calcium channels.
- Molecular Biology & Recombinant Protein Technology – applying molecular tools to study protein function and expression at laboratory and pilot scales, including the production of recombinant proteins as biologics for therapeutic and diagnostic applications. This work extends to scaling up these products for industrial manufacture and developing business models to bring innovations to market.
By integrating these research areas, my research aims to provide deeper insights into epithelial physiology, contribute to the development of targeted biomedical interventions, and support innovation in translational medicine and biomedical engineering.
1.Vilà-González M, Pinte L, Fradique R, Causa E, Kool H, Rodrat M, Morell CM, Al-Thani M, Porter L, Guo W, Maeshima R, Hart SL, McCaughan F, Granata A, Sheppard DN, Floto RA, Rawlins EL, Cicuta P, Vallier L. In vitro platform to model the function of ionocytes in the human airway epithelium. Respir Res. 2024;25(1):180. doi: 10.1186/s12931-024-02800-7
2.1,2Li H, 1Rodrat M, Al-Salmani MK, Veselu DF, Han ST, Raraigh KS, Cutting GR, Sheppard DN. Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor. J Physiol. 2024;602:333-354.
1 H Li and M Rodrat co-first author
2 Article the subject of a commentary (Csanády L. J Physiol. 2024;602:257-258)
3.Rodrat M, Wongdee K, Chankamngoen W, Teerapornpuntakit J, Thongbunchoo J, Tanramluk D, Charoenphandhu N. Modulation of fibroblast growth factor-23 expression and transepithelial calcium absorption in Caco-2 monolayer by calcium-sensing receptor and calcineurin under calcium hyperabsorptive state. Biochem Biophys Res Commun. 2023;659:105-112.
4.Rodrat M, Wongdee K, Teerapornpuntakit J, Thongbunchoo J, Tanramluk D, Aeimlapa R, Thammayon N, Thonapan N, Wattano P, Charoenphandhu N. Vasoactive intestinal peptide and cystic fibrosis transmembrane conductance regulator contribute to the transepithelial calcium transport across intestinal epithelium-like Caco-2 monolayer. PLoS One. 2022;17:e0277096.
5.Noel S, Servel N, Hatton A, Golec A, Rodrat M, Ng DRS, Li H, Pranke I, Hinzpeter A, Edelman A, Sheppard DN, Sermet-Gaudelus I. Correlating genotype with phenotype using CFTR-mediated whole-cell Cl- currents in human nasal epithelial cells. J Physiol. 2022;600:1515-1531.
– Travel Grant Award, 47th European Cystic Fibrosis Conference, Glasgow, United Kingdom, 5 – 8 June 2024
– Third prize winner in poster competition at UK Cystic Fibrosis Conference, London, 3 October, 2023
– Early Career Researcher poster communication competition prize winner at Membrane Transport 2023: Recent Research into Ion Channels, Transporters and Epithelial Physiology, St Andrews, United Kingdom, 24 – 25 August 2023
– Best poster award in the category of Cell Biology/Physiology/New Therapies/Clinical Trials, 42nd European Cystic Fibrosis Conference, Liverpool, United Kingdom, 5 – 8 June 2019
– Most Engaging Exhibit and Most Popular Vote prizes for presentation on cystic fibrosis research at University’s festival of postgraduate research for the public “Research Without Borders 2019”, University of Bristol, Bristol, United Kingdom, 15 May 2019
– Outstanding Oral Presentation award, 19th RGJ-Ph.D. Congress, Chonburi, Thailand, 7−9 June 2018
– PSJ2018 Travel Grant Award, the 95th Annual Meeting of the Physiological Society of Japan, Takamatsu, Kagawa, Japan, 28−30 March 2018
– The Royal Golden Jubilee Ph.D. Program Scholarship 2015
